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Case report: Surgical treatment of McCune-Albright syndrome with hyperthyroidism and retrosternal goiter: A case report and literature review.

Front Surg

January 2023

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Introduction: McCune-Albright syndrome (MAS) is a low-incidence syndrome consisting of the clinical triad of fibrous structural dysplasia of bone, endocrine disease, and skin pigmentation. Thyroid dysfunction is the second most common endocrine dysregulation in MAS. However, there are no treatment guidelines for MAS complicated with hyperthyroidism.

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Circulating glucagon to ghrelin ratio as a determinant of insulin resistance in hyperthyroidism.

Endocrine

February 2014

Department of Endocrinology and Metabolic Diseases, Faculty of Medicine, Ibn-I Sina Hospital, Ankara University, Sihhiye, Ankara, Turkey,

Due to stimulated overall metabolism, a state of nutritional inadequacy often ensues, during thyrotoxicosis. We aimed to investigate circulating levels of some major components of the system that regulates energy stores, glucose, and fat metabolism, during thyrotoxicosis compared to euthyroidism. Fasting serum ghrelin, leptin, adiponectin, insulin, glucagon, glucose, as well as body fat composition were analyzed during thyrotoxicosis in 40 hyperthyroid patients (50.

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The findings in hyperthyroid patients with Graves' orbitopathy (GO) of antibodies against antigens shared between the thyroid and orbit, such as the TSH-receptor (TRAb) and a novel protein G2s (G2sAb), suggested a possible common therapeutic strategy. However, the gold therapeutic standard for hyperthyrodism in these patients remains still unsettled and is mainly based on personal experience. Studies on the effect of total thyroidectomy (TT) alone or followed by radioiodine ablation (RAI) of thyroid remnants showed often conflicting results.

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[Subclinical thyroid disease].

Praxis (Bern 1994)

December 2007

Medizinische Poliklinik, Universitätsspital Basel.

Subclinical thyroid dysfunction is a frequent disorder characterized by abnormal levels of thryotropin (TSH) and normal thyoid hormones. Subclinical hypothyroidism can be associated with unspecific symptoms and dyslipidemia, a substitution is generally recommended if the TSH is > 10 microU/l. With lower TSH-levels, the indication for substitution is individual, depending on other risk factors or diseases like dyslipidemia, smoking, goiter, pregnancy or clinical symptoms.

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The radioiodine therapy can favour and induces of autommunological reaction in thyroid gland. The aim of the study was evaluation of antithyroid autoantibodies in patients with multinodular large toxic goiter treated with repeated doses of 131I before and after therapy. Studies were conducted in 24 women (age range: 65-84 yrs) with multinodular large toxic goiters--goiter volume assessed by USG over 100 ml.

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