We examined the nature of contralateral damage following unilateral orchitis to see if an immunologically mediated mechanism was present. Experimentally induced orchitis in 18 white New Zealand rabbits were examined and compared to 20 in the control groups. Serum antisperm antibody presence and bilateral testicular biopsies (Johansen biopsy score, mean seminiferous tubule diameter) were examined and pregnancy rates were noted. Acute orchitis seemed to be a causative factor in production of antisperm antibody and the presence of antisperm antibody caused histologic changes in contralateral testicles and therefore impaired fertility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF02549538 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Human Papillomavirus (HPV) on Male and Female Fertility.
Pathogens
December 2024
Department of Infectious Agents and Hygiene, University Hospital of Saint-Etienne, 42023 Saint-Etienne, France.
Human papillomaviruses (HPVs) are responsible for the majority of sexually transmitted infections (STIs), some of which are oncogenic and can cause oropharyngeal or genital cancers. The HPV prevalence at the genital level varies according to the population studied but is higher in the seminal fluid of men suffering from idiopathic infertility than in the general population. The involvement of HPV in male infertility is supported by several studies suggesting that this virus can affect sperm quality by altering sperm DNA integrity, motility, number, viability, and morphology, and by inducing the production of anti-sperm antibodies (ASAs).
View Article and Find Full Text PDFImpact of infection on semen parameters and fertilization outcomes in infertile men.
Front Endocrinol (Lausanne)
December 2024
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Introduction: (UU) is a common pathogen associated with genital tract infections in infertile males. However, its impact on semen quality, embryo development, and fertilization (IVF) outcomes remains underexplored. This study aims to evaluate the effect of male UU infection on semen parameters, embryo development, pregnancy outcomes, and neonatal health in infertile couples.
View Article and Find Full Text PDFArticle Synopsis
- The incomplete understanding of epididymal mucosal immunity complicates the diagnosis of many male infertility cases, often leaving them labeled as idiopathic.
- Disruptions like vasectomy or infections can trigger immune responses against sperm, leading to autoimmune reactions and chronic subfertility issues.
- The research highlights the role of regulatory T cells and the formation of tertiary lymphoid structures in the epididymis, indicating potential avenues for targeted infertility treatments and male contraceptive developments.
Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes.
Asian J Androl
November 2024
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Ureaplasma urealyticum (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who underwent IUI at The First Affiliated Hospital of USTC (Hefei, China) between January 2021 and January 2023. The subjects were classified into two groups according to their UU infection status: the UU-positive group and the UU-negative group.
View Article and Find Full Text PDF[Treatment of male immune infertility by traditional Chinese medicine: A meta-analysis].
Zhonghua Nan Ke Xue
June 2024
Department of Andrology / Reproductive Medicine, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan 650021, China.
Article Synopsis
- Scientists did a study to check if traditional Chinese medicine (TCM) is good for treating male immune infertility.
- They looked at 25 medical trials and found that TCM works better than Western medicine in helping men with this problem.
- TCM not only helped improve sperm health and pregnancy rates but also caused fewer side effects. *
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!