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Research note: The critical role of the interaction between Eimeria tenella invasion protein RON2 and host receptor annexin A2 in mediating parasite invasion.
Poult Sci
December 2024
Guangdong Province Key Laboratory of Livestock Disease Prevention, Key Laboratory of Avian Infuenza and Other Major Poultry Diseases Prevention and Control, Ministry of Agriculture and Rural Afairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China. Electronic address:
Avian coccidiosis, caused by protozoan parasites of the genus Eimeria, is a globally prevalent and highly pathogenic disease that poses a serious threat to the poultry industry, resulting in significant economic losses. However, the mechanism by which Eimeria species invade host cells remains unclear. Previous studies have identified rhoptry neck protein 2 (RON2) from Eimeria tenella as a critical factor in host cell invasion, but a comprehensive understanding of the role of EtRON2 in host cell invasion and its relationship with E.
View Article and Find Full Text PDFSilicone oil, an intraocular surgical adjuvant, induces retinal ferroptosis.
Free Radic Biol Med
December 2024
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, 466-8560, Japan; Department of Ophthalmology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3125, Japan. Electronic address:
Vitrectomy with silicone oil (SO) endotamponade is an effective treatment for vision-threatening retinal diseases. However, unexplained vision impairment has been reportedly critical side effects. Previously, we reported that the eyes with ocular toxoplasmosis showed retinal ferroptosis with the clinical sign of reduced intravitreal iron (Fe).
View Article and Find Full Text PDFIsatin-1,2,3-triazole derivatives: Synthesis, molecular docking and evaluation against acute experimental toxoplasmosis.
Acta Trop
December 2024
Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, 21577, Egypt.
Toxoplasmosis remains a challenge for both public health and animal husbandry which created a constant demand to develop novel compounds using innovative methods. To join this relentless quest for an ideal chemotherapeutic agent, herein, we developed newly synthesized isatin-1,2,3-triazole derivatives. Three compounds (5a, 5b and 5c) were synthesized, characterized, loaded on chitosan nanoparticles (CNPs) and then evaluated accordingly.
View Article and Find Full Text PDFFrequency of exposure to Toxoplasma gondii in COVID-19 patients: a systematic review and meta-analysis.
BMC Public Health
October 2024
Master of Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, 15067, Peru.
Background: Toxoplasmosis is a chronic protozoan parasitic infection that affects nearly one-third of the global population. During the COVID-19 pandemic, cases were observed in patients with COVID-19 and toxoplasmosis. Therefore, this systematic review and meta-analysis aimed to determine the frequency of Toxoplasma gondii exposure in patients with COVID-19.
View Article and Find Full Text PDFMolecular prevalence, epidemiology, and phylogenetic analysis of Babesia microti in dogs with a note on its impact on host hematological profile.
Vet Parasitol Reg Stud Reports
October 2024
Department of Zoology, The Islamia University Bahawalpur, 60800, Pakistan. Electronic address:
Babesia (B.) microti is an intra-erythrocytic protozoan parasite that infects humans as well as domestic and wild animals. Prevalence of B.
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