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Hyaluronan: an overview.
J Biol Regul Homeost Agents
December 2017
Università Campus Bio-Medico di Roma, Rome, Italy.
Hyaluronic acid (HA) is a polyanionic natural polymer occurring as a linear polysaccharide composed of glucuronic acid and N-acetylglucosamine repeats. Hyaluronic acid has a wide range of applications with its excellent physicochemical properties such as biodegradability, biocompatibility, non-toxicity, non-immunogenicity and serves as an excellent tool in biomedical applications such as osteoarthritis surgery, ocular surgery, plastic surgery, tissue engineering and drug delivery. This work provides an overview on hyaluronic acid, its chemistry and biochemistry and its medical applications.
View Article and Find Full Text PDFMetabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption.
Drug Metab Dispos
August 2009
Plant Products and Human Nutrition Group, Division of Environmental and Evolutionary Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK.
Human subjects drank coffee containing 412 mumol of chlorogenic acids, and plasma and urine were collected 0 to 24 h after ingestion and were analyzed by high-performance liquid chromatography-mass spectrometry. Within 1 h, some of the components in the coffee reached nanomole peak plasma concentrations (C(max)), whereas chlorogenic acid metabolites, including caffeic acid-3-O-sulfate and ferulic acid-4-O-sulfate and sulfates of 3- and 4-caffeoylquinic acid lactones, had higher C(max) values. The short time to reach C(max) (T(max)) indicates absorption of these compounds in the small intestine.
View Article and Find Full Text PDFNMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of Ibuprofen ((+/-)-(R,S)-2-(4-isobutylphenyl) propanoic acid), its metabolites, and analogues.
Anal Chem
November 2007
Department of Biomolecular Medicine, Division of Surgery, Oncology, Reproductive Biology and Anaesthetics (SORA), Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, U.K.
Carboxylic acid-containing drugs are often metabolized to 1-beta-O-acyl glucuronides (AGs). These can undergo an internal chemical rearrangement, and the resulting reactive positional isomers can bind to endogenous proteins, with clear potential for adverse effects. Additionally any 1-beta-O-acyl-glucuronidated phase I metabolite of the drug can also show this propensity, and investigation of the adverse effect potential of a drug also needs to consider such metabolites.
View Article and Find Full Text PDF[Effect of alginic acid and its salts on the dynamic of 85Sr and 137Cs accumulation in rats].
Radiats Biol Radioecol
December 1994
Accumulation of 85Sr and 137Cs radionuclide blend in rats was studied. Effect of alginic acid, its salts as well as foods containing the polysaccharides on dynamics of accumulation was established. It was shown that efficiency of compounds studied depends on type of salt of alginic acid and presence of guluronic acid in it.
View Article and Find Full Text PDF[Inhibitory effect on anti-lipid IV antiserum binding activity of various synthetic oligosaccharides].
Yakugaku Zasshi
May 1994
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Me beta 1-4Fuc of lipid IV, inhibited but precursors (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared.
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