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Rapid access to functionalized nanographenes through a palladium-catalyzed multi-annulation sequence.
Chem Sci
January 2025
Institute of Chemistry, Academia Sinica 128 Academia Road, Section 2, Nankang Taipei 115201 Taiwan
Nanographenes and polycyclic aromatic hydrocarbons exhibit many intriguing physical properties and have potential applications across a range of scientific fields, including electronics, catalysis, and biomedicine. To accelerate the development of such applications, efficient and reliable methods for accessing functionalized analogs are required. Herein, we report the efficient synthesis of functionalized small nanographenes from readily available iodobiaryl and diarylacetylene derivatives a one-pot, multi-annulation sequence catalyzed by a single palladium catalyst.
View Article and Find Full Text PDFChanges in doxylamine-pyridoxine dispensation in Ontario following media attention: Time-series analysis.
Can Fam Physician
January 2025
Assistant Professor in the Leslie Dan Faculty of Pharmacy at the University of Toronto, Scientist at Women's College Hospital Institute for Health System Solutions and Virtual Care in Toronto, Investigator with the Ontario Drug Policy Research Network, and Adjunct Scientist at ICES.
Objective: To understand the possible association between media coverage and changes in the dispensation of doxylamine-pyridoxine in Canada.
Design: Cross-sectional time-series analysis using data from the IQVIA CompuScript database.
Setting: Ten Canadian provinces.
Interaction of normelinonine F and related N-methyl-β-carbolines derivatives with bovine serum albumin. Spectroscopic profiles, multivariate analysis and theoretical calculations.
Int J Biol Macromol
January 2025
Instituto Tecnológico de Chascomús (CONICET-UNSAM), Av. Intendente Marino Km 8.2, CC 164, B7130IWA Chascomús, Argentina; Escuela de Bio y Nanotecnologías (UNSAM), Argentina. Electronic address:
β-carbolines (βCs) represent a large family of bioactive alkaloids, including norharmane and normelinonine F, known for their diverse pharmacological activities. The effects of these alkaloids may depend, among other factors, on their delivery, accumulation in different subcellular compartments, and interactions with biomacromolecules such as serum albumins. In this study, we investigated the pH dependence of the interactions between bovine serum albumin (BSA) and four βCs (norharmane, normelinonine F, and their corresponding N(9)-methyl derivatives) using UV-vis and fluorescence spectroscopy, combined with multivariate analysis and molecular docking.
View Article and Find Full Text PDFanalysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells.
World J Gastroenterol
January 2025
Department of Oncology Surgery, Cell Therapy and Organ Transplantation, Institute of Biomedicine of Seville, Virgen del Rocio University Hospital, Seville 41013, Spain.
Background: Hepatocellular carcinoma (HCC) is the most common subtype of primary liver cancer with varied incidence and epidemiology worldwide. Sorafenib is still a recommended treatment for a large proportion of patients with advanced HCC. Different patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 cells.
View Article and Find Full Text PDFE-cigarettes, synthetic nicotine, heated-tobacco and smokeless nicotine delivery products: the nicotine landscape beyond combustible cigarettes.
Swiss Med Wkly
November 2024
Department of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Cigarette smoking remains an enormous public health problem causing millions of preventable deaths annually worldwide. Although safe and efficient smoking cessation pharmacotherapies such as nicotine replacement products and the medications varenicline and bupropion are available, long-term abstinence rates remain low and new approaches to help smokers successfully quit smoking are needed. In recent years, electronic nicotine delivery systems such as e-cigarettes and heated-tobacco products, and novel smokeless nicotine delivery products like nicotine pouches have gained widespread popularity.
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