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Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment.
J Adv Res
January 2025
Department of General/Emergency, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin 300070, China; Tianjin Medical University Institute of Stomatology, No.12 Qixiangtai Road, Heping District, Tianjin 300070, China. Electronic address:
Introduction: The acidic microenvironment caused by excessive lactate accumulation could inhibit immune lymphocytes antitumor activity and promote the immune escape of tumor cells. Baicalin is an active flavonoid isolated from Scutellaria baicalensis Georgi, a traditional Chinese medicinal herb with antioxidant and anti-inflammatory properties.
Objectives: The present study aims to investigate whether and how baicalin inhibits oral squamous cell carcinoma (OSCC) acidic microenvironment and attenuates immune escape.
The Anti-Inflammatory Effects of Formononetin, an Active Constituent of Var. , via Modulation of Macrophage Autophagy and Polarization.
Molecules
January 2025
College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China.
var. (Willd.) Maesen & S.
View Article and Find Full Text PDFSystematic Characterization of the Chemical Constituents of in Vitro and in Vivo of Astragali Radix-Salvia miltiorrhiza Herb Pair by Ultra-High-Performance-Liquid Chromatography-Orbitrap Mass Spectrometry.
Rapid Commun Mass Spectrom
April 2025
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Rationale: Astragali radix-Salvia miltiorrhiza (AR-SM) is an herb pair with good therapeutic effects and is widely used. In this study, the in vitro and in vivo components of AR-SM were quickly classified and identified based on UHPLC-orbital mass spectrometry. This provided a basis for clarifying the bioactive substances after compatibility of AR and SM.
View Article and Find Full Text PDFTraditional Uses, Bioactive Compounds, and New Findings on Pharmacological, Nutritional, Cosmetic and Biotechnology Utility of .
Nutrients
December 2024
Department of Medicinal Plant and Mushroom Biotechnology, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, 30-688 Cracow, Poland.
(L.) Medik. (shepherd's purse) is a medicinal plant recently introduced to European Pharmacopoeia.
View Article and Find Full Text PDFRevealing the Mechanism of Baroni in Depression Treatment Through Integrated Network Pharmacology and Transcriptomic Analysis.
Pharmaceuticals (Basel)
December 2024
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 102488, China.
: Baroni (HCB) is a traditional herb for the treatment of depression in China. However, the active constituents and the underlying mechanisms of its antidepressant effects remain unclear. The aim of this study was to identify the bioactive constituents of HCB and elucidate its underlying mechanism for the treatment of depression.
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