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Naturally Occurring Anti-D in a Male Blood Donor, Unresolved Mystery.
Indian J Hematol Blood Transfus
October 2024
Department of Immunohematology and Blood Transfusion, Medical College, Bharati Vidyapeeth Deemed University, Pune Satara Road, 411043 Dhankawadi, Pune, Maharashtra India.
In accordance with numerous national and international criteria, screening donated blood for abnormal antibodies against red cell antigens is crucial for patient safety. Antibodies can be formed by three mechanisms: by immune responses, naturally occurring, or passively acquired. In accordance with departmental policy, ICT was performed on a 30-yearold male blood donor's sample in addition to ABO Rh grouping.
View Article and Find Full Text PDFADA2 regulates inflammation and hematopoietic stem cell emergence via the AR pathway in zebrafish.
Commun Biol
May 2024
Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, L.I.T.A., via Fratelli Cervi 93, Segrate, 20054, Milan, Italy.
Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormalities, culminating in bone marrow failure. A major gap exists in our knowledge of the regulatory functions of ADA2 during inflammation and hematopoiesis, mainly due to the absence of an ADA2 orthologue in rodents.
View Article and Find Full Text PDFChallenges in the diagnosis and management of autoimmune hemolytic anemia: A case-based approach. Experience from a tertiary care hospital in the Haryana region.
Indian J Pathol Microbiol
October 2024
Department of Transfusion Medicine and Hematology, ESIC Medical College and Hospital, Faridabad, Haryana, India.
Article Synopsis
- Autoimmune hemolytic anemia (AIHA) is a rare condition where the body's immune system attacks its own red blood cells, causing them to break down, and can be classified into different types.
- Researchers studied 11 patients suspected of having AIHA to understand how it works and what treatments might help them.
- Most of the patients had a type called secondary AIHA, with some having warm AIHA and others having mixed AIHA; accurate testing is important for correct diagnosis and treatment.
infection alters the intestinal mucosa transcriptome in neonatal calves: implications for immune function.
Front Immunol
February 2024
Research Institute for Farm Animal Biology, Institute of Nutritional Physiology "Oskar Kellner", Dummerstorf, Germany.
One of the leading causes of infectious diarrhea in newborn calves is the apicomplexan protozoan (). However, little is known about its immunopathogenesis. Using next generation sequencing, this study investigated the immune transcriptional response to infection in neonatal calves.
View Article and Find Full Text PDFPharmacological NF-κB inhibition decreases cisplatin chemoresistance in muscle-invasive bladder cancer and reduces cisplatin-induced toxicities.
Mol Oncol
December 2023
Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Most patients with muscle-invasive bladder cancer (MIBC) are not cured with platinum chemotherapy. Up-regulation of nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) is a major mechanism underlying chemoresistance, suggesting that its pharmacological inhibition may increase platinum efficacy. NF-κB signaling was investigated in two patient cohorts.
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