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Objective: This study evaluated the diagnostic value of plasma Neutrophil extracellular traps (NETs) levels and the index of cardiac electrophysiological balance (iCEB) in identifying silent myocardial ischemia (SMI) in maintenance hemodialysis (MHD) patients.

Methods: This cross-sectional observational study involved patients receiving MHD treatment. Data were collected on coronary angiography performed in our hospital from February 2023 to February 2024.

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Ventricular Depolarization Abnormalities and Their Role in Cardiac Risk Stratification - A Narrative Review.

Rev Cardiovasc Med

January 2025

Department of Cardiovasculair Sciences, KU Leuven, 3000 Leuven, Belgium.

Ventricular depolarization refers to the electrical activation and subsequent contraction of the ventricles, visible as the QRS complex on a 12-lead electrocardiogram (ECG). A well-organized and efficient depolarization is critical for cardiac function. Abnormalities in ventricular depolarization may indicate various pathologies and can be present in all leads if the condition is general, or in a subgroup of anatomically contiguous leads if the condition is limited to the corresponding anatomic location of the heart.

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Objectives: This study was performed to assess the accuracy of standard electrocardiographic criteria in diagnosing of right ventricular (RV) involvement in patients with inferior myocardial infarction (IMI).

Methods: This was a retrospective analysis of patients admitted with an IMI. Proximal occlusion of the right coronary artery before the origin of the RV branch on angiography was considered diagnostic of RV involvement.

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Effects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor planning: a multimodal signal study.

Cogn Neurodyn

December 2025

College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072 China.

Motor planning plays a pivotal role in daily life. Transcutaneous auricular vagus nerve stimulation (taVNS) has been demonstrated to enhance decision-making efficiency, illustrating its potential use in cognitive modulation. However, current research primarily focuses on behavioral and single-modal electrophysiological signal, such as electroencephalography (EEG) and electrocardiography (ECG).

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This analysis assessed the relationship between the plasma concentrations of loperamide and its N-desmethyl loperamide meta- bolite (M1) and the potential QT interval prolongation at therapeutic and supratherapeutic doses. The exposure-response analysis was performed using the data from healthy adults participating in a randomized, double-blind, single-dose, four-way (placebo; loperamide 8 mg [therapeutic]; loperamide 48 mg [supratherapeutic]; moxifloxacin 400 mg [positive control]) crossover study. The electrocardiographic measurements extracted from 12-lead digital Holter recordings were time-matched to pharmacokinetic sampling of loperamide/M1.

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