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Construction of a multifunctional bio-probe based on lanthanides for UCL/MR/CT multimodal imaging in vivo.
Biomed Mater
December 2024
Yijishan Hospital of Wannan Medical College, No.2 Zheshan West Road, Wuhu City, Anhui Province, Wuhu, Anhui, 241001, CHINA.
Multimodal bioimaging is beneficial for clinical diagnosis and research due to the provision of comprehensive diagnostic information. However, the design of multifunctional bio-probes aggregating multiple bioimaging functions is greatly challenging. In this study, a multifunctional bio-probe based on lanthanide-based nanomaterials Sr2GdF7: Yb3+/Er3+/Tm3+ (abbreviated as SGF) was developed for in vivo multimodal imaging by co-adopting apropos lanthanides and tuning their molar ratio.
View Article and Find Full Text PDFA systematic review and meta-analysis: prevalence and clinical implications of anatomical variants of the hepatic portal vein.
Sci Rep
December 2024
Faculty of Health and Social Sciences, Universidad de Las Américas, Santiago, 8370040, Chile.
Article Synopsis
- The hepatic portal vein (HPV) collects blood from several organs including the liver and intestines, and plays a key role in metabolizing blood components.
- The study aimed to analyze the characteristics of HPV variants and their clinical implications, utilizing multiple databases and data from 31 studies, focusing mostly on research from Europe and Asia.
- Findings revealed varying prevalence of HPV anatomical variants, which are important for medical professionals to consider in diagnosis and surgical procedures due to their potential impact on abdominal cavity health.
Lyophilised protein formulations as a patient-centric dosage form: A contribution toward sustainability paradigm.
Acta Pharm
June 2024
1University of Ljubljana, Faculty of Pharmacy, Department of Pharmaceutical Technology, 1000 Ljubljana, Slovenia.
Article Synopsis
- - Society is focusing on the need for innovative pharmaceutical technologies to address challenges like population aging and climate change, particularly targeting patient-specific drug delivery systems.
- - The development of protein drugs for subcutaneous administration is crucial but faces challenges such as maintaining protein stability and appropriate formulation viscosity during manufacturing.
- - A study using bovine serum albumin explored how protein concentration impacts the quality of liquid and lyophilized formulations, confirming that higher concentrations lead to increased viscosity and longer reconstitution times, while identifying the critical role of sucrose and the need to balance it with mannitol in lyophilization.
The pivotal role of compelling high-risk electrocardiographic markers in prediction of ventricular arrhythmic risk in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis.
Curr Probl Cardiol
February 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Jl. Pasteur No.38, Pasteur, Kec. Sukajadi, Bandung, Jawa Barat, Indonesia.
Introduction: Several investigations have shown that existing risk stratification processes remain insufficient for stratifying sudden cardiac death risk in arrhythmogenic right ventricular cardiomyopathy (ARVC). Multiple auxiliary parameters are investigated to offer a more precise prognostic model. Our aim was to assess the association between several ECG markers (epsilon waves, prolonged terminal activation duration (TAD) of QRS, fragmented QRS (fQRS), late potentials on signal-averaged electrocardiogram (SA-ECG), T-wave inversion (TWI) in right precordial leads, and extension of TWI in inferior leads) with the risk of developing poor outcomes in ARVC.
View Article and Find Full Text PDFRibbing's disease is a rare form of sclerosing bone dysplasia characterized by exuberant yet benign endosteal bone, and periosteum formation in the diaphysis of long bones. Diagnosis relies on exclusionary criteria, as the primary clinical manifestations entail progressive pain unresponsive to analgesic therapy, accompanied by serological markers within normal ranges. Pain management constitutes the cornerstone of treatment, with surgery appearing to offer the most efficacious approach, despite the absence of a standardized therapeutic algorithm.
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