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Bacterial over-production of the functionally active human SLC38A2 (SNAT2) exploiting the mistic tag: a cheap and fast tool for testing ligands.
Mol Biol Rep
February 2024
Department DiBEST (Biologia, Ecologia, Scienze Della Terra) Laboratory of Biochemistry, Molecular Biotechnology and Molecular Biology, University of Calabria, Via P. Bucci 4C-6C, 87036, Arcavacata di Rende, Italy.
Background: SLC38A2 is a ubiquitously expressed Na-dependent transporter specific for small and medium neutral amino acids. It is involved in human pathologies, such as type II diabetes and cancer. Despite its relevance in human physio-pathology, structure/function relationship studies and identification of ligands with regulatory roles are still in infancy.
View Article and Find Full Text PDFKnockdown of small nucleolar RNA host gene 10 (SNHG10) alleviates the injury of human neuroblastoma cells via the miR-1277-5p/insulin substrate receptor 2 axis.
Bioengineered
January 2022
Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, Shandong, China.
Parkinson's disease is a common neurodegenerative disease with a complex physio-pathology. So far, there is no effective medical strategies to prevent the progression of Parkinson's disease. Understanding the mechanisms underlying the progression of Parkinson's disease could provide insights into the formulation of novel preventative or treatment strategies.
View Article and Find Full Text PDFAdipoRon negatively regulates proliferation and migration of ARPE-19 human retinal pigment epithelial cells.
Peptides
December 2021
CEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145, Napoli, Italy; Dipartimento di Medicina Molecolare e Biotecnologie Mediche, "Federico II" Università degli Studi di Napoli, Napoli, 80131, Italy.
Adiponectin is an adipokine playing important roles in metabolic, inflammatory and proliferative processes. At the time of surgery for rhegmatogenous retinal detachment, an altered expression of adipokines has been associated with the development of future proliferative vitreoretinopathy (PVR); this evidence as well as the presence of adiponectin receptors in ocular tissues and cell lines suggests a role of adiponectin in the physio-pathology of ocular conditions. Here, we investigated the effects of AdipoRon, an adiponectin agonist, on ARPE-19, a human retinal pigment epithelial cell line after confirming the expression of AdipoR1, AdipoR2, T-cadherin receptors.
View Article and Find Full Text PDFCarbonic anhydrase inhibitors as antitumor/antimetastatic agents: a patent review (2008-2018).
Expert Opin Ther Pat
October 2018
a Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences , University of Florence, Sesto Fiorentino (Firenze) , Italy.
Introduction: Human carbonic anhydrases (CA, EC 4.2.1.
View Article and Find Full Text PDFSerotonin: a double-edged sword for the liver?
Surgeon
April 2012
Department of surgery, Laboratory of the Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland.
Since the discovery of the impact of serotonin in liver regeneration, this molecule has gained considerable attention in liver physio-pathology. Platelet-derived serotonin initiates liver regeneration after partial hepatectomy in various rodent models. Serotonin agonism stabilizes the hepatic microcirculation and prevents small-for-size liver graft failure.
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