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A Rare Case of Hyperglycemia, Ketoacidosis, and Central Facial Paralysis in a Newly-Diagnosed Diabetic Woman.
Am J Case Rep
June 2024
Department of Neurology, Cayenne Hospital Center, Cayenne, French Guiana.
BACKGROUND Diabetes mellitus is a chronic disease that occurs when the pancreas does not produce enough insulin or when the body is unable to effectively use the insulin it produces. Uncontrolled diabetes mellitus is usually associated with neurological manifestations, such as hemichorea, focal epileptic seizures, peripheral neuropathy, and peripheral facial paralysis. This report describes a 59-year-old woman presenting with hyperglycemia and ketoacidosis due to newly diagnosed diabetes mellitus, as well as a temporary episode of central facial paralysis, which regressed within a few days after medical treatment and metabolic correction.
View Article and Find Full Text PDFIntracranial bifocal germinoma.
Radiol Case Rep
September 2022
Department of Radiology - CHU Hassan II. Faculty of Medicine and Pharmacy, Sidi Mohamed BenAbdellah University. Fez, Morocco.
Primary intracranial germ cell tumors are rare, often affecting children and young patients. Germinomas are the most common type of germ cell tumors. We present the case of a 10-year-old child, who was admitted with decreased visual acuity, asthenia, polyuro-polydipsic syndrome, and gait disorder.
View Article and Find Full Text PDF[Central diabetes insipidus].
Rev Prat
April 2022
Service d'endocrinologie, diabétologie, maladies métaboliques, hôpital Avicenne, Bobigny, France Laboratoire Éducations et Pratiques de santé, EA 3412, université Sorbonne Paris Nord, France.
"Central diabetes insipidus Diabetes insipidus may remain undetected for a long time, the ionogram remaining normal as long as polydipsia compensates for diuresis. In the first place, and by argument of frequency, polyuria should rule out diabetes. Diabetes insipidus is evoked in the presence of an incapacitating polyuro polydipsic syndrome, especially at night.
View Article and Find Full Text PDFV2R mutations and nephrogenic diabetes insipidus.
Prog Mol Biol Transl Sci
July 2011
Canada Research Chair in Genetics of Renal Diseases, Groupe d'Etude des Protéines Membranaires, Montréal, Québec, Canada.
Nephrogenic diabetes insipidus (NDI), which can be inherited or acquired, is characterized by an inability to concentrate urine despite normal or elevated plasma concentrations of the antidiuretic hormone, arginine vasopressin (AVP). Polyuria, with hyposthenuria, and polydipsia are the cardinal clinical manifestations of the disease. Nephrogenic failure to concentrate urine maximally may be due to a defect in vasopressin-induced water permeability of the distal tubules and collecting ducts, to insufficient buildup of the corticopapillary interstitial osmotic gradient, or to a combination of these two factors.
View Article and Find Full Text PDFHereditary polyuric disorders: new concepts and differential diagnosis.
Semin Nephrol
May 2006
Groupe d'Etude des Protéines Membranaires; and the Université de Montréal, Research Centre and Nephrology Service, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, Canada.
The identification, characterization, and mutational analysis of genes coding for key proteins to the mechanisms of urine concentration provide the basis for understanding the 2 types of hereditary nephrogenic diabetes insipidus (NDI): a pure type characterized by loss of water only, and a complex type characterized by loss of water and ions. Patients with hereditary NDI bearing mutations in AVPR2, the gene coding for the arginine vasopressin 2 receptor, or in AQP2, the gene coding for the vasopressin-sensitive water channel, have a pure NDI phenotype with loss of water, but normal conservation of sodium, potassium, chloride, and calcium. Patients bearing inactivating mutations in 1 of the 5 genes (SLC12A1, KCNJ1, CLCNKB, CLCNKA, and CLCNKB in combination, or BSND) that encode the membrane proteins of the thick ascending limb of the loop of Henle have a complex polyuro-polydipsic syndrome with loss of water, sodium, chloride, calcium, magnesium, and potassium.
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