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Deamination mechanism of modified magnesium slag using wet aging and its performance evolution as backfill material.
J Environ Manage
January 2025
School of Business, Xi'an University of Finance and Economics, Xi'an, 710100, China.
The purpose of this study is to solve the problem of ammonia (NH) release when modified magnesium slag (MMS) is used as coal mine backfill cementitious material, and to explore its chemical mechanism and put forward effective solutions. Uniaxial compressive strengths (UCS) hydration kinetics, scanning electron microscope (SEM), and thermogravimetric analysis-derivative thermogravimetry (TG-DTG), X-ray diffractometer (XRD) and other testing methods were used to study the evolution of the properties of MMS-based backfill material, which provided a scientific basis for the safe utilization of MMS. First, the chemical mechanism underlying the release of NH from MMS was identified, and it was confirmed that MgN and LiN are the main nitrogen sources.
View Article and Find Full Text PDFEffect of Bovine Serum Albumin (BSA) Concentration on Cryopreservation of Booroolong Frog Sperm with Evaluation of Post-Thaw Motility in Caffeine.
Vet Sci
January 2025
Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Mosman, NSW 2088, Australia.
Reproductive technologies, including sperm cryopreservation, offer conservationists enhanced capacity to genetically manage populations and improve the outcomes of conservation breeding programs (CBPs). Despite this potential, the post-thaw quality of amphibian sperm is highly variable following cryopreservation, and research focused on protocol refinement is needed. The aim of this study was twofold: (1) to investigate the effect of the addition of bovine serum albumin (BSA) to the cryopreservation medium (pre-freeze), and (2) the effect of the addition of caffeine to the activation medium (post-thaw), on post-thaw sperm characteristics in the critically endangered Booroolong frog ().
View Article and Find Full Text PDFLocally Employed Doctors and International Medical Graduates in the NHS: Current and Evolving Trends.
Br J Hosp Med (Lond)
December 2024
Endocrinology, Diabetes and General (Internal) Medicine, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, North Staffordshire, UK.
Locally Employed Doctors (LEDs) are defined as any doctor below consultant grade, appointed within a UK National Health Service (NHS) Trust, who are not working within a national training scheme. They are a cohort significantly increasing in numbers. International Medical Graduates (IMGs) are overseas-qualified doctors who contribute to more than 30% of the workforce-related deficit in the number of UK-qualified doctors required to meet NHS requirements.
View Article and Find Full Text PDFInterrogation of the tumor microenvironment by nanoparticles.
Cancer Lett
January 2025
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA; Peggy and Charles Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA. Electronic address:
The tumor microenvironment (TME) plays a pivotal role in cancer progression by fostering intricate multicellular crosstalk among cancer cells, stromal cells, and immune cells. This review explores the emerging paradigm of utilizing nanoparticles to disrupt this crosstalk within the TME as a therapeutic strategy. Nanoparticles are engineered with precise physicochemical properties to target specific cell types and deliver therapeutic payloads, thereby inhibiting critical signaling pathways involved in tumor growth, invasion, and metastasis.
View Article and Find Full Text PDF3D printing of different fibres towards HA/PCL scaffolding induces macrophage polarization and promotes osteogenic differentiation of BMSCs.
PLoS One
January 2025
Department of Orthopaedic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Honghuagang District, Guizhou, China.
With the rise of bone tissue engineering (BET), 3D-printed HA/PCL scaffolds for bone defect repair have been extensively studied. However, little research has been conducted on the differences in osteogenic induction and regulation of macrophage (MPs) polarisation properties of HA/PCL scaffolds with different fibre orientations. Here, we applied 3D printing technology to prepare three sets of HA/PCL scaffolds with different fibre orientations (0-90, 0-90-135, and 0-90-45) to study the differences in physicochemical properties and to investigate the response effects of MPs and bone marrow mesenchymal stem cells (BMSCs) on scaffolds with different fibre orientations.
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