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Progressive supranuclear palsy: an updated approach on diagnosis, treatment, risk factors and outlook in Mexico.
Gac Med Mex
January 2025
Laboratorio de Reprogramación Celular y Enfermedades Crónico-Degenerativas, Department of Physiology, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Progressive supranuclear palsy (PSP) is a rare, atypical parkinsonism, characterized by the presence of intracerebral tau protein aggregates and determined by a wide spectrum of clinical features. The definitive diagnosis is postmortem and is identified through the presence of neuronal death, gliosis, and aggregates of the tau protein presented in the form of neurofibrillary tangles (MNF) with a globose appearance in regions such as the subthalamic nucleus, the substantia nigra, and the globus pallidus The findings in ancillary imaging studies, as well as fluids biomarkers, are not sufficient to support diagnosis of PSP but are used to rule out similar pathologies because there are still no specific or validated biomarkers for this disease. The current treatment of PSP is focused on reducing symptoms, although emerging therapies seek to counteract its pathophysiological mechanisms.
View Article and Find Full Text PDFAnalysis of Drug-Related Tinnitus Based on the FDA Adverse Event Reporting System Database.
Br J Hosp Med (Lond)
December 2024
Department of Otolaryngology Head and Neck Surgery, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, China.
Tinnitus is a very common condition, and is a side effect of many medications. The panorama of drug-induced tinnitus has widened in recent decades, and post-marketing data are needed to gain a better insight into adverse drug reactions related to tinnitus. However, there are currently few studies on drug-induced tinnitus.
View Article and Find Full Text PDFSmoothed Particle Hydrodynamics for free-surface and multiphase flows: a review.
Rep Prog Phys
January 2025
Istituto di Ingegneria del Mare Consiglio Nazionale delle Ricerche, Via di Vallerano 139, Roma, Lazio, 00128, ITALY.
The Smoothed Particle Hydrodynamics (SPH) method is expanding and applied to more and more fields, particularly in engineering. The majority of current SPH developments deal with free-surface and multiphase flows, especially for situations where geometrically complex interface configurations are involved. The present review article covers the last 25 years of development of the method to simulate such flows, discussing the related specific features of the method.
View Article and Find Full Text PDFPANORAMA: A 2021 Clinician Survey of Treatment Approaches for People With New Diagnoses of Relapsing-Remitting Multiple Sclerosis in the United Kingdom.
Int J MS Care
January 2025
Novartis Pharmaceuticals UK Ltd, London, United Kingdom.
Background: The PANORAMA survey aimed to assess current treatment practice for individuals with new diagnoses of relapsing-remitting multiple sclerosis (RRMS) in the United Kingdom and to explore variations in treatment approaches with an emphasis on escalation vs early high-efficacy treatment (HET) and treatment goals.
Methods: Health care professionals (HCPs) from the UK treating patients with RRMS took part in interviews facilitated by a structured questionnaire. Data were analyzed descriptively using quantitative or qualitative methods, as appropriate.
Comparative genomics of the sexually transmitted parasite reveals relaxed and convergent evolution and genes involved in spillover from birds to humans.
bioRxiv
December 2024
Center for Genomics and Systems Biology, New York University, 12 Waverly Place, New York, NY 10003, USA.
is the causative agent of the venereal disease trichomoniasis which infects men and women globally and is associated with serious outcomes during pregnancy and cancers of the human reproductive tract. Trichomonads parasitize a range of hosts in addition to humans including birds, livestock, and domesticated animals. Recent genetic analysis of trichomonads recovered from columbid birds has provided evidence that these parasite species undergo frequent host-switching, and that a current epoch spillover event from columbids likely gave rise to in humans.
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