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E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model.
Arch Toxicol
January 2025
Department of Medicine, University of California, San Diego, CA, 92093, USA.
E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.
View Article and Find Full Text PDFAdenomatous Polyposis Coli (APC) Promoter Gene Methylation in Urine-Derived DNA: A Non-invasive Biomarker for Early Bladder Cancer Detection and Tumor Aggressiveness.
Cureus
October 2024
Laboratory of Virology, Oncology, Biosciences, Environment and New Energies, Faculty of Sciences and Techniques Mohammedia, University Hassan II of Casablanca, Mohammedia, MAR.
Background Bladder urothelial carcinoma (BLCA) is a major cause of morbidity and mortality worldwide, largely due to the high frequency of disease relapse and the lack of efficient endoscopic diagnostic methods. This study aimed to address this clinical gap by evaluating the potential of using adenomatous polyposis coli (APC) gene promoter methylation as a biomarker detectable in urine DNA of individuals with BLCA. Methods Methylation-specific PCR was used to determine the methylation status of the APC promoter gene in 50 bladder carcinoma patients and 50 apparently healthy individuals.
View Article and Find Full Text PDFAssessment of the frequency and risk factors for colorectal cancer in acromegaly.
Endocrine
November 2024
Endocrine Unit and Neuroendocrinology Research Center, Medical School, and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Article Synopsis
- Acromegaly is linked to an uncertain increased risk for colorectal cancer (CRC), prompting this study to evaluate the prevalence of colonic adenomatous polyps and CRC in acromegaly patients during colonoscopies.
- The study involved 123 patients and found that the majority had non-neoplastic findings at their first colonoscopy, with a small percentage developing CRC over time; risk factors like age and smoking were significantly associated with neoplasia.
- Findings indicate that older age (specifically over 50) and smoking elevate the risk of colonic lesions, suggesting that the recommended screening age for CRC in those with acromegaly may need to be reconsidered.
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model.
bioRxiv
August 2024
Department of Medicine, University of California, San Diego, CA, 92093, USA.
Background: E-cigarettes (E.cigs) cause inflammation and damage to human organs, including the lungs and heart. In the gut, E.
View Article and Find Full Text PDFDifferent modifiable risk factors for the development of non-advanced adenoma, advanced adenomatous lesion, and sessile serrated lesions, on screening colonoscopy.
Sci Rep
July 2024
Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, 260 Gonghangdaero, Gangseo-gu, Seoul, 07804, Korea.
The development of premalignant colorectal polyps is significantly influenced by various lifestyle and modifiable risk factors. In our study, we used a large cohort of 9025 patients, who underwent screening colonoscopies at a university hospital, to assess the risk factors associated with the development of three different colorectal cancer precursor lesions: non-advanced adenomas (NAs), advanced adenomatous lesions (ADLs), and sessile serrated lesions (SSLs). Among the participants, 3641 had NAs, 836 had ADLs, and 533 had SSLs.
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