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Homeostasis is a driving principle in physiology. To achieve homeostatic control of neural activity, neurons monitor their activity levels and then initiate corrective adjustments in excitability when activity strays from a set point. However, fluctuations in the brain microenvironment, such as temperature, pH, and other ions represent some of the most common perturbations to neural function in animals.
View Article and Find Full Text PDFThe legalization of cannabis in several states across the US has increased the need to better understand its effects on the body, brain, and behavior, particularly in different populations. Rodent models are particularly valuable in this respect because they provide precise control over external variables. Previous rodent studies have found age and sex differences in response to injected Δ -tetrahydrocannabinol (THC), the major psychoactive component of cannabis.
View Article and Find Full Text PDFIntraoperative vascular anastomosis occlusion due to cold agglutinin disease during brain surgery: a case report.
JA Clin Rep
January 2025
Department of Anesthesiology and Pain Medicine, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Background: Cold agglutinin disease (CAD) is an autoimmune hemolytic anemia that induces blood coagulation and hemolysis upon exposure to cold temperatures. Strict temperature control is essential to mitigate these effects, especially during surgical procedures where hypothermia is possible.
Case Presentation: A 57-year-old male, 165 cm and 72 kg, diagnosed with CAD, underwent cerebral vascular anastomosis.
Population variation in fatty acid composition and response to climatic factors in Malania oleifera Chun et S.K. Lee.
BMC Plant Biol
January 2025
Key Laboratory of National Forestry and Grassland Administration on Plant Ex Situ Conservation, Beijing Floriculture Engineering Technology Research Centre, Beijing Botanical Garden, Beijing, 100093, China.
Malania oleifera Chun et S.K. Lee is a woody oil tree species and is rich in nervonic acid, which is associated with brain development.
View Article and Find Full Text PDFMechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.
Nat Metab
January 2025
Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut.
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