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[Application of PMS2 and MSH6 double-antibody detection in screening of mismatch repair deficient tumors].
Zhonghua Bing Li Xue Za Zhi
February 2025
Department of Pathology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Article Synopsis
- The study investigated the effectiveness of using two immunohistochemical markers (PMS2 and MSH6) as a replacement for four markers (MLH1, PMS2, MSH2, MSH6) in detecting mismatch repair deficient (dMMR) cancers across nearly 8,000 cases.
- The results indicated high consistency between the two marker sets, with Cohen κ values ranging from 0.88 to 1.00, and overall sensitivity and specificity for 2-MMR at 99.6% and 100%, respectively.
- The findings suggest that the more streamlined 2-MMR could effectively replace 4-MMR for dMMR screening due to its high reliability, with only a minuscule
A Narrative Review of Molecular, Immunohistochemical and In-Situ Techniques in Dermatopathology.
Br J Biomed Sci
January 2025
St. John's Dermatopathology Laboratory, Synnovis Analytics, St. Thomas' Hospital, London, United Kingdom.
Article Synopsis
- Skin disorders are a major global health issue, affecting millions and requiring improved understanding and treatment approaches.
- Recent advancements in molecular techniques, like PCR and next-generation sequencing, have enhanced our ability to diagnose and treat these disorders accurately and effectively.
- These technologies allow for precise identification of infectious agents, genetic mutations, and gene expression patterns, leading to personalized therapies and better management of conditions like skin cancer and infections.
Ehrlichia sp. in dairy cattle from Bahia, Brazil: high seropositivity rates and molecular confirmation of Ehrlichia minasensis.
BMC Vet Res
December 2024
Departamento de Anatomia, Patologia e Clínicas Veterinárias, Universidade Federal da Bahia, Escola de Medicina Veterinária e Zootecnia, Av. Milton Santos 500, Salvador, Bahia, CEP 40170-110, Brazil.
Background: Ehrlichia spp. are obligate intracytoplasmic Gram-negative tickborne bacteria from the Anaplasmataceae family. Ehrlichiosis is considered an emerging disease in humans and animals.
View Article and Find Full Text PDFMicrosatellite instability and high tumor mutational burden detected by next generation sequencing are concordant with loss of mismatch repair proteins by immunohistochemistry.
Cancer Genet
January 2025
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:
Impairment of DNA mismatch repair function in neoplasms can be assessed by DNA-based methods to assess for high microsatellite instability (MSI-High) or immunohistochemical (IHC) analysis to assess for deficiency of mismatch repair proteins (dMMR). Neoplasms with mismatch repair deficiency often have high tumor mutational burden (TMB-High). MSI-High, dMMR, and TMB-High are all histology agnostic biomarkers for potential therapy using immune checkpoint inhibitors (ICI).
View Article and Find Full Text PDFGenomic Alterations in DNA Mismatch Repair Genes Across Different Cancer Types.
JCO Precis Oncol
November 2024
Department of Investigational Cancer Therapeutics (Phase 1 Program), The University of Texas MD Anderson Cancer Center, Houston, TX.
Article Synopsis
- PD-1 inhibition shows effectiveness in treating patients with mismatch repair deficient (dMMR) solid tumors; however, routine testing for dMMR using immunohistochemistry (IHC) is not common across different tumor types.
- A study involving over 15,000 solid tumor patients demonstrated that next-generation sequencing (NGS) can help identify mutations in MMR genes, revealing a correlation with IHC results in those tested.
- The findings indicate that patients with MMR mutations showed a significant rate of dMMR, highlighting the potential benefits of employing IHC testing on patients with identified MMR mutations to optimize treatment options.
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