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Sci Rep
March 2025
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits. While acute treatment may alleviate immediate symptoms, the long-term consequences, particularly those involving neuroinflammation and systemic toxicity, remain poorly understood. This study used adult male and female Sprague Dawley rats to investigate the chronic effects of a single acute exposure to soman (132 µg/kg, s.
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To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Cruciate Ligament Transection (ACLT) + Medial Meniscectomy (MMx). Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination.
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Sci Rep
March 2025
Jinan Hangchen Biotechnology Co., Ltd., Jinan, 250000, China.
Fucoidan is a fucose-rich sulfated polysaccharide that has gained attention owing to its various biological activities. In this study, fucoidan was isolated from Saccharina japonica using an enzyme-assisted method, and its antioxidant and anti-hepatocarcinoma effects were evaluated. The fucoidan was a 112.
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Objective: We evaluated two SDS-based preparation methods for direct identification of yeasts using MALDI-TOF MS analysis and antifungal susceptibility testing (AFST).
Methods: A total of 149 residual monomicrobial blood culture bottles (BCs) were included. For direct identification via MALDI-TOF MS analysis from positive BCs, two in-house methods with or without a 3-hr incubation step were evaluated.
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Bioresour Technol
March 2025
Center for Environmental Research and Sustainable Technology (UFT), University of Bremen, Bremen, Germany. Electronic address:
Background: A sustained presence on Mars requires the production of food on site, but farming is limited by the local availability of suitable nutrients. Cyanobacteria can feed on Martian resources, and we hypothesized that the nutrients they mobilize could be extracted through anaerobic digestion and used as crop fertilizer.
Methods: We therefore tested the abilities of three microbial communities to digest the biomass of Anabaena sp.
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