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Carbon dioxide narcosis following cesarean section in a patient with severe pulmonary hypertension: A case report.
Medicine (Baltimore)
October 2024
Department of Anesthesiology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Rationale: Managing anesthesia in patients with severe pulmonary conditions involves complex considerations, especially when dealing with high baseline CO2 levels. We present a case that demonstrates the challenges and complexities of anesthesia and postoperative analgesia in a patient with severe pulmonary hypertension and a history of lung disease exacerbated by the interactions of protein-bound drugs.
Patient Concerns: A 37-year-old woman at 38 weeks of gestation presented with recurrent chest tightness, shortness of breath, and worsening symptoms over a week, which required emergency medical attention.
Intravenous ketamine successfully treats treatment-resistant catatonia in schizophrenia: A case report.
Pharmacotherapy
October 2024
Houston Methodist Hospital, Houston, Texas, USA.
Article Synopsis
- Benzodiazepines and ECT are primary treatments for catatonia, which can arise from psychiatric or medical conditions, but when they're ineffective, ketamine has been explored as an alternative therapy.
- A case study highlighted a 77-year-old woman with treatment-resistant catatonia due to schizophrenia, who showed a rapid recovery after a single ketamine infusion when ECT was unavailable during the pandemic.
- While ketamine may be a promising option for drug-resistant catatonia, it needs to be used carefully because it could potentially worsen psychosis in patients with schizophrenia, indicating the need for more research in this area.
Combined effects of mild hypothermia and nitrous-oxide-induced narcosis on manual and cognitive performance.
Am J Physiol Regul Integr Comp Physiol
March 2024
Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden.
Divers are at enhanced risk of suffering from acute cognitive deterioration because of the low ambient temperatures and the narcotic action of inert gases inspired at high pressures. Yet, the behavioral effects of cold and inert gas narcosis have commonly been assessed in isolation and during short-term provocations. We therefore evaluated the interactive influence of mild hypothermia and narcosis engendered by a subanesthetic dose of nitrous oxide (NO; a normobaric intervention analog of hyperbaric nitrogen) on cognitive function during prolonged iterative exposure.
View Article and Find Full Text PDFNitrous oxide consistently attenuates thermogenic and thermoperceptual responses to repetitive cold stress in humans.
J Appl Physiol (1985)
September 2023
Division of Environmental Physiology, Swedish Aerospace Physiology Center, KTH Royal Institute of Technology, Stockholm, Sweden.
Divers are at enhanced risk of hypothermia, due to the independent action of the inspired inert gases on thermoregulation. Thus, narcosis induced by acute (≤2 h) exposure to either hyperbaric nitrogen or normobaric nitrous oxide (NO) impairs shivering thermogenesis and accelerates body core cooling. Animal-based studies, however, have indicated that repeated and sustained NO administration may prevent NO-evoked hypometabolism.
View Article and Find Full Text PDFMedetomidine/midazolam/fentanyl narcosis alters cardiac autonomic tone leading to conduction disorders and arrhythmias in mice.
Lab Anim (NY)
April 2023
Medizinische Klinik und Poliklinik I, University Hospital Munich, Campus Grosshadern and Innenstadt, Ludwig-Maximilians University Munich (LMU), Munich, Germany.
Arrhythmias are critical contributors to cardiovascular morbidity and mortality. Therapies are mainly symptomatic and often insufficient, emphasizing the need for basic research to unveil the mechanisms underlying arrhythmias and to enable better and ideally causal therapies. In translational approaches, mice are commonly used to study arrhythmia mechanisms in vivo.
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