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Retinal Docosahexaenoic Acid Is Significantly Reduced in Diabetic Humans and Mice: Possible Relationship to Diabetic Retinopathy.
Invest Ophthalmol Vis Sci
December 2024
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States.
Purpose: The retina contains the highest concentration of the omega 3 fatty acid, docosahexaenoic acid (DHA), in the body. Although epidemiologic studies showed an inverse correlation between the consumption of omega 3 fatty acids and the prevalence of diabetic retinopathy, there are no data showing the effect of diabetes on retinal DHA in humans. In this study, we measured the DHA content of the retina in diabetic and non-diabetic humans as well as mice and determined the effect of diabetes on retinal thickness and function in mice.
View Article and Find Full Text PDFMetabolomic Profile Modification in the Cerebellum of Mice Repeatedly Exposed to Khat and Treated with β-Lactamase Inhibitor, Clavulanic Acid.
Metabolites
December 2024
Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
Background/objectives: Catha edulis, commonly known as khat, is used for its psychoactive effects and is considered a natural amphetamine. The current study investigated the metabolomic profile in the cerebellum of mice after repeated exposure to khat and evaluated the effects of clavulanic acid on the metabolomic profile in the cerebellum in khat-treated mice.
Methods: Male C67BL/6 mice that were 6-9 weeks old were recruited and divided into three groups: the control group was treated with 0.
Chemical Diversity of Mediterranean Seagrasses Volatilome.
Metabolites
December 2024
CNRS, Aix-Marseille University, Avignon University, IRD, UMR 7263 IMBE, 13397 Marseille, France.
Background/objectives: Biogenic volatile organic compounds (BVOCs), extensively studied in terrestrial plants with global emissions around 1 PgC yr, are also produced by marine organisms. However, benthic species, especially seagrasses, are understudied despite their global distribution (177,000-600,000 km). This study aims to examine BVOC emissions from key Mediterranean seagrass species (, , , and ) in marine and coastal lagoon environments.
View Article and Find Full Text PDFMicrobiological Aspects and Enzymatic Characterization of L7: Ascomycete with Great Biomass Degradation Potentialities.
J Fungi (Basel)
November 2024
Dipartmento di Scienze Agrarie, Alimentari e Forestali, Università degli Studi di Palermo, 90133 Palermo, Italy.
The complex structure of the plant cell wall makes it difficult to use the biomass produced by biosynthesis. For this reason, the search for new strains of microorganisms capable of efficiently degrading fiber is a topic of interest. For these reasons, the present study aimed to evaluate both the microbiological and enzymatic characteristics of the fungus L7strain.
View Article and Find Full Text PDFMachine Learning and Metabolomics Predict Mesenchymal Stem Cell Osteogenic Differentiation in 2D and 3D Cultures.
J Funct Biomater
December 2024
BioMedical Systems Engineering Laboratory, Panoz Institute, School of Pharmacy and Pharmaceutical Sciences, Trinity College, D02 PN40 Dublin, Ireland.
Stem cells have been widely used to produce artificial bone grafts. Nonetheless, the variability in the degree of stem cell differentiation is an inherent drawback of artificial graft development and requires robust evaluation tools that can certify the quality of stem cell-based products and avoid source-tissue-related and patient-specific variability in outcomes. Omics analyses have been utilised for the evaluation of stem cell attributes in all stages of stem cell biomanufacturing.
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