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Influences of roughness and filling degree on the shear strength and damage evolution characteristics of cement-filled joints.
PLoS One
January 2025
School of Resources and Environmental Engineering, Wuhan University of Science and Technology, Wuhan, China.
The shear resistance of filling joints is an important factor affecting the stability of rock joints. Pressure-shear tests of cement-filled joints were carried out. Combined with the acoustic emission (AE) technique, the effects of normal stress, roughness and filling degree on the shear strength, damage morphology and damage evolution of cement-filled joints were investigated.
View Article and Find Full Text PDFAnalysis of the effect of joint roughness on the failure mechanism of jointed rock mass under direct shear loading.
PLoS One
January 2025
School of Civil Engineering, Guizhou University, Guiyang, Guizhou, China.
The mechanical properties of jointed rock bodies are important in guiding engineering design and construction. Using the particle flow software PFC2D, we conducted direct shear test simulations on joints with various inclinations and five different roughness levels to examine the models' crack extension penetration paths, damage modes, and strength characteristics. The findings indicate that the direction of the joint influences the pattern of the rock crack and its penetration route.
View Article and Find Full Text PDFMetabolic Scaling: Exploring the Relation Between Metabolic Rate and Body Size.
Adv Physiol Educ
January 2025
Emeritus, Department of BioSciences, Rice University, Houston, Texas.
We present an alternative to the traditional classroom lecture on the topics of metabolic scaling, allometric relationships between metabolic rate (MR) and body size, and reasons for rejecting Rubner''s surface "law," concepts that students have described as challenging, counterintuitive, and/or mathematical. In groups, students work with published data on MR and body size for species representing all five vertebrate groups. To support the exercise, we developed a worksheet that has students define the concept in their own words, compare different measures of MR, and evaluate plots of MR and mass-specific MR versus body mass for both homeotherms and poikilotherms.
View Article and Find Full Text PDFPharmacokinetic and Exposure-Response Modeling Support Body Surface Area-Based Dosing of Farletuzumab Ecteribulin in Japanese Patients with Solid Tumors.
J Clin Pharmacol
January 2025
Eisai Inc., Nutley, NJ, USA.
The first-in-human, Phase 1 Study 101 showed antitumor activity and a tolerable safety profile of farletuzumab ecteribulin in Japanese patients with platinum-resistant ovarian and non-small cell lung cancer. A pharmacometric assessment evaluated farletuzumab ecteribulin pharmacokinetics and exposure-response (E-R) relationships for efficacy and safety to support dose optimization. Patients received 0.
View Article and Find Full Text PDFChlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ, and J:ARC(S) Mice Following Exposure to Shedding Mice.
Comp Med
December 2024
1Tri-Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, and The Rockefeller University, New York, New York.
Chlamydia muridarum (Cm) has reemerged as a moderately prevalent infectious agent in research mouse colonies. Despite its experimental use, few studies evaluate Cm's effects on immunocompetent mice following its natural route of infection. A Cm field isolate was administered (orogastric gavage) to 8-wk-old female BALB/cJ (C) mice.
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