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New lesions after MDT in PB and MB leprosy: a report of 28 cases.
Indian J Lepr
May 2009
Department of Dermatology, STDs and Leprosy, Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi-110001, India.
Appearance of new skin and/or nerve lesions during or after fixed duration of multi drug therapy (MDT), both in multibacillary (MB) and paucibacillary (PB) leprosy, is not uncommon. It could be a lesion due to reaction (type 1 or type 2), relapse due to multiplication of persisting or drug resistant bacilli or reinfection due to re-entry of lepra bacilli from outside. It is relatively easier to recognize the lesions due to classical reaction, both clinically and histopathologically.
View Article and Find Full Text PDFA comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients.
Acta Leprol
December 1999
Department of Medical Microbiology and Parasitology, University College of Medicine, Calcutta, India.
Anergy, or contrarily, Mitsuda-type responses towards 4 chemoautotrophic nocardioform antigens (CAN-Ags) and a control standard lepromin were tested in 73 LL, TT and borderline cases of leprosy. The antigens injected per patient varied from a maximum of 5 to a minimum of 2. Complete anergy to CAN-Ags was seen in 92/92 instances tested on 24 LL cases.
View Article and Find Full Text PDFSensitization and reactogenicity of two doses of candidate antileprosy vaccine Mycobacterium w.
Indian J Lepr
March 1997
CJIL Field Unit (ICMR), Avadi, Madras.
M.w vaccine is one of the antileprosy vaccines under test in an ongoing comparative vaccine trial in South India. The objective of the present study was to examine the sensitizing ability, as measured by skin test reactions to Rees' MLSA and lepromin, and reactogenicity of M.
View Article and Find Full Text PDFPost-vaccination sensitization with ICRC vaccine.
Indian J Lepr
December 1996
CJIL Field Unit (ICMR), Madras.
ICRC vaccine is one of the candidate anti-leprosy vaccines under test in a large scale comparative vaccine in trial. The objectives of the present study was to study the sensitization potential, as measured by Rees' MLSA and lepromin, and reactogenicity of this vaccine preparation in the local population. The study included 368 'healthy' individuals aged 1-70 years.
View Article and Find Full Text PDFImmunohistochemical study of cutaneous neuritis in positive lepromin reactions.
Lepr Rev
December 1995
Dermatology Service, Hospital de Clinicas, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Sixty skin biopsies taken from positive tuberculoid and borderline-tuberculoid late lepromin reaction were studied using histological techniques. The distribution of mycobacterial antigen and nerves was demonstrated using immunochemical methods. A total of 557 nerve bundles was observed in 51 biopsies; 9 were devoid of nerves in the sections examined; 475 nerve bundles showed some relationship to the inflammatory infiltrate (85%); perineuritis being seen in 144 (30%) and endoneuritis in 5 (0.
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