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Mitochondrial fission and fusion in neurodegenerative diseases:Ca signalling.
Mol Cell Neurosci
January 2025
Xiangya School of Public Health, Central South University, Changsha, Hunan Province, PR China. Electronic address:
Neurodegenerative diseases (NDs) are a group of disorders characterized by the progressive loss of neuronal structure and function. The pathogenesis is intricate and involves a network of interactions among multiple causes and systems. Mitochondria and Ca signaling have long been considered to play important roles in the development of various NDs.
View Article and Find Full Text PDFChallenges and compromises: Predicting unbound antibody structures with deep learning.
Curr Opin Struct Biol
January 2025
Oxford Protein Informatics Group, Department of Statistics, University of Oxford, 24-29 St Giles', Oxford, OX1 3LB, United Kingdom.
Therapeutic antibodies are manufactured, stored and administered in the free state; this makes understanding the unbound form key to designing and improving development pipelines. Prediction of unbound antibodies is challenging, specifically modelling of the CDRH3 loop, where inaccuracies are potentially worse due to a bias in structural data towards antibody-antigen complexes. This class imbalance provides a challenge for deep learning models trained on this data, potentially limiting generalisation to unbound forms.
View Article and Find Full Text PDFRetinal OCT image classification based on MGR-GAN.
Med Biol Eng Comput
January 2025
School of Automation and Information Engineering, Sichuan University of Science & Engineering, Key Laboratory of Artificial Intelligence, Yibin, 644000, Sichuan, China.
Accurately classifying optical coherence tomography (OCT) images is essential for diagnosing and treating ophthalmic diseases. This paper introduces a novel generative adversarial network framework called MGR-GAN. The masked image modeling (MIM) method is integrated into the GAN model's generator, enhancing its ability to synthesize more realistic images by reconstructing them based on unmasked patches.
View Article and Find Full Text PDFAndrogenic Anabolic Steroids Cause Thiol Imbalance in the Vascular Endothelial Cells.
Front Biosci (Landmark Ed)
January 2025
Department of Cytobiology and Proteomics, Medical University of Lodz, 92-215 Lodz, Poland.
Background: Androgenic anabolic steroids (AASs) are synthetic drugs structurally related to testosterone, with the ability to bind to androgen receptors. Their uncontrolled use by professional and recreational sportspeople is a widespread problem. AAS abuse is correlated with severe damage to the cardiovascular system, including changes in homeostasis and coagulation disorders.
View Article and Find Full Text PDFSpirulina Supplementation Alleviates Intense Exercise-Induced Damage and Modulates Gut Microbiota in Mice.
Nutrients
January 2025
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Ningbo University, Ningbo 315211, China.
Background: , which are filamentous cyanobacteria, have gained significant popularity in the food industry, medicine, and aquaculture.
Methods: In this study, our objective was to explore the influence of on the gut microbiota and exercise capacity of mice undergoing high-intensity exercise. Twenty-four male BALB/c mice were divided into four groups, with six mice in each group.
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