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Aim: To detect in patients with psoriasis the adverse effects during TNF-a inhibitor therapy.
Material And Methods: Fifty-seven patients with psoriasis, aged between 12 and 75 years were analyzed. They were treated with different TNF-α antagonists, the maximum treatment duration being 59 months.
[Results of skin tests to assess drug-induced allergy].
Ann Dermatol Venereol
November 2010
Hôpital Fournier, Nancy, France.
Background: Skin tests are often used to explore adverse drug reactions. The sensitivity of skin tests appears to vary according to the drugs tested and the type of adverse reaction in question. There is no clear strategy to explore drug adverse reactions.
View Article and Find Full Text PDF[Chronic actinic dermatitis. Therapy with systemic PUVA and mycophenolate mofetil].
Hautarzt
July 2011
Universitäts-Hautklinik, Universitäts-Klinikum Tübingen, Eberhard Karls Universität, Liebermeisterstr. 25, 72076, Tübingen, Deutschland.
A 66-year-old man was diagnosed with psoriasis in 2001 and treated accordingly; in 2007, the diagnosis was switched to atopic dermatitis and the therapy modified. Initially he improved with fumarates and methotrexate, but then experienced recurrent exacerbations with erythroderma and severe superinfection requiring hospitalization. Based on the modified clinical picture with striking accentuation on the head and back of the hands, we diagnosed chronic actinic dermatitis.
View Article and Find Full Text PDFDrug neosensitization during anticonvulsant hypersensitivity syndrome.
J Investig Allergol Clin Immunol
December 2006
Allergy Unit, Hospital Universitari Joan XXIII, Tarragona, Spain.
Anticonvulsant hypersensitivity syndrome (AHS) is a rare, severe drug hypersensitivity reaction included in the drug-related rash with eosinophilia and systemic symptoms syndrome (DRESS), in which a transient state of immune suppression and reactivation of latent virus infections have been observed. We describe 5 patients who developed neosensitization to different drugs taken during a previous episode of anticonvulsant-related DRESS, in whom skin prick, intradermal and/or patch tests were performed to confirm the diagnosis of drug hypersensitivity. In 1 patient, transient hypogammaglobulinemia was observed during the AHS.
View Article and Find Full Text PDFSevere adverse cutaneous reaction to insulin due to cresol sensitivity.
Contact Dermatitis
August 2006
Birmingham Skin Centre, Sandwell and West Birmingham NHS Trust, Birmingham B18, UK.
We present the case of an 80-year-old lady known to be sensitive to chlorocresol (4-chloro-3-methyl phenol) who developed severe erythrodermic exfoliative dermatitis with atypical features 2 weeks after commencing subcutaneous insulin. All medications except insulin were stopped, without major improvement. It was noted that the insulin contained m-cresol (m-methyl phenol) so a parabens-based insulin was substituted.
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