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Background: Juxtaglomerular (JG) cells are sensors that control blood pressure and fluid-electrolyte homeostasis. In response to a decrease in perfusion pressure or changes in the composition and/or volume of the extracellular fluid, JG cells release renin, which initiates an enzymatic cascade that culminates in the production of angiotensin II (Ang II), a potent vasoconstrictor that restores blood pressure and fluid homeostasis. In turn, Ang II exerts a negative feedback on renin release, thus preventing excess circulating renin and the development of hypertension.
View Article and Find Full Text PDFTcf21 as a founder transcription factor in specifying Foxd1 cells to the juxtaglomerular cell lineage.
Am J Physiol Renal Physiol
January 2025
Division of Pediatric Nephrology, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States.
Renin is crucial for blood pressure regulation and electrolyte balance, and its expressing cells arise from Forkhead box D1-positive (Foxd1) stromal progenitors. However, factors guiding these progenitors toward renin-secreting cell fate remain unclear. Tcf21, a basic helix-loop-helix (bHLH) transcription factor, is essential in kidney development.
View Article and Find Full Text PDFPiezo channels in JG cells do not regulate renin expression or renin release to the circulation.
Clin Sci (Lond)
December 2024
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Article Synopsis
- Renin-expressing juxtaglomerular (JG) cells have a mechanism that senses pressure and regulates renin release based on changes in blood flow.
- The study investigates whether Piezo2 receptors, known for their role in detecting touch, play a role in controlling renin synthesis and release in JG cells.
- Results show that Piezo2 channels are not necessary for renin release or synthesis in JG cells under normal or stressed conditions, suggesting that other mechanisms need to be identified.
A Case of Acquired Cystic Kidney Disease From Chronic Renal Failure Without Dialysis.
Cureus
September 2024
Internal Medicine, Baptist Health South Florida, Miami, USA.
Article Synopsis
- * A 78-year-old man with a history of heart issues presented with end-stage renal disease and severe anemia after a fall at home, with lab results showing extremely high creatinine and blood urea nitrogen levels.
- * Imaging revealed numerous renal cysts, and despite no family history of polycystic kidney disease, his case highlights the importance of thorough evaluation for rare conditions like acquired cystic kidney disease before starting dialysis.
A Possible Link between Cell Plasticity and Renin Expression in the Collecting Duct: A Narrative Review.
Int J Mol Sci
September 2024
Department of Physiology and Pathophysiology, Center of Biomedical Education and Research (ZBAF), Faculty of Health-School of Medicine, Witten/Herdecke University, 58453 Witten, Germany.
The hormone renin is produced in the kidney by the juxtaglomerular cells. It is the rate-limiting factor in the circulating renin-angiotensin-aldosterone system (RAAS), which contributes to electrolyte, water, and blood pressure homeostasis. In the kidneys, the distal tubule and the collecting duct are the key target segments for RAAS.
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