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Impact of High Glucose on Bone Collagenous Matrix Composition, Structure, and Organization: An Integrative Analysis Using an Ex Vivo Model.
Cells
January 2025
Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, 4200-393 Porto, Portugal.
Diabetes mellitus is a widespread metabolic disorder linked to numerous systemic complications, including adverse effects on skeletal health, such as increased bone fragility and fracture risk. Emerging evidence suggests that high glucose may disrupt the extracellular matrix (ECM) of bone, potentially altering its composition and organization. Collagen, the primary organic component of the ECM, is critical for maintaining structural integrity and biomechanical properties.
View Article and Find Full Text PDF1. The heritability (h) of liveweight (LW) in ostriches can be highly variable, depending on age at recording. The objective of this study was to consider random regression (RR) as an alternative to the multi-trait (MT) structure for the analysis of repeated measures of LW.
View Article and Find Full Text PDFStored elastic bending tension as a mediator of embryonic body folding.
Cell Rep
January 2025
Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel. Electronic address:
During development, amniote vertebrate embryos transform from a flat sheet into a three-dimensional cylindrical form through ventral folding of the lateral sides of the sheet (the lateral plate [LP]) and their fusion in the ventral midline. Using a chick embryo slice system, we find that the flat stage is actually a poised balance of opposing dorsal and ventral elastic bending tensions. An intact extracellular matrix (ECM) is required for generating tension, as localized digestion of ECM dissipates tension, while removal of endoderm or ectoderm layers has no significant effect.
View Article and Find Full Text PDFGinseng glucosyl oleanolate inhibit cervical cancer cell proliferation and angiogenesis via PI3K/AKT/HIF-1α pathway.
NPJ Sci Food
December 2024
College of Food Science and Engineering, Jilin Agricultural University, Changchun, China.
Ginseng (Panax ginseng C.A. Meyer) is widely used in several functional foods at present.
View Article and Find Full Text PDFAnalysis of bioactive compounds of hen egg components at the first half of incubation.
J Food Sci
December 2024
Faculty of Medicine and Biology, North-Caucasus Federal University, Stavropol, Russia.
A comparative analysis of mass-volume characteristics of structural and morphological components of hen eggs before incubation and on the fifth (HH25-HH27) and 10th (HH36) days of incubation was carried out. During incubation, egg weight decreased by 9.25% (10 days), mainly due to a decrease in albumen weight (35.
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