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An Unusual and Severe Thyrotoxicosis in a Twin Pregnancy: Fortune Favors the Brave.
Case Rep Endocrinol
January 2025
Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Graves' disease (GD) and gestational transient thyrotoxicosis (GTT) are the most common causes of thyrotoxicosis during pregnancy, with prevalence ranging from 0.1% to 1% and from 1% to 3%, respectively. Hyperthyroidism during pregnancy can have severe consequences if not promptly recognized and treated.
View Article and Find Full Text PDFRenal Outcomes and Other Adverse Effects of Cannabinoid Supplementation.
Nutrients
December 2024
Department of Nephrocardiology, Medical University of Lodz, 90-549 Lodz, Poland.
This narrative review explores the benefits and risks of cannabinoids in kidney health, particularly in individuals with pre-existing renal conditions. It discusses the roles of cannabinoid receptor ligands (phytocannabinoids, synthetic cannabinoids, and endocannabinoids) in kidney physiology. The metabolism and excretion of these substances are also highlighted, with partial elimination occurring via the kidneys.
View Article and Find Full Text PDFMulti-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.
Res Sq
December 2024
Department of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.
While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child outcomes. Herein we performed a multi-ancestry genome-wide association study (GWAS) of severe nausea and vomiting of pregnancy of 10,974 cases and 461,461 controls across European, Asian, African, and Latino ancestries. We identified ten significantly associated loci, of which six were novel (, , , , , and , and confirmed previous genome-wide significant associations with risk genes , , , and .
View Article and Find Full Text PDFElectrolyte imbalance and liver function test abnormalities among pregnant women with hyperemesis gravidarum at Wag-himra zone public hospitals, Northeast Ethiopia, 2023: a comparative cross-sectional study.
Front Med (Lausanne)
December 2024
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Hyperemesis gravidarum affects about 4.8% of pregnant women. It can lead to electrolyte imbalances and liver function disturbances, which may result in pregnancy complications.
View Article and Find Full Text PDFAssessment of adverse pregnancy outcomes associated with Helicobacter pylori infection.
Sci Rep
December 2024
Department of Gynecology and Obstetrics, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sect. 4 , Taichung, 40705, Taiwan.
The background of Helicobacter pylori (H. pylori) infection is complex, and its influence on adverse pregnancy outcomes is inconsistently reported. We performed a multi-institutional, retrospective analysis using de-identified electronic health records from the TriNetX Research Network to compare various pregnancy outcomes in women with and those without H.
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