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Swift energy shift: Acute exercise reduces cerebral glucose metabolism in cognitively healthy older adults and individuals with Alzheimer's disease.
J Physiol
January 2025
Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.
Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy.
Proc Natl Acad Sci U S A
January 2025
Department of Pathology, University of California San Diego, La Jolla, CA 92093.
We hypothesized that a strategy employing tissue-specific endothelial cells (EC) might facilitate the identification of tissue- or organ-specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water-soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4 lymphoma extracts.
View Article and Find Full Text PDFAnnexin A8 deficiency delays atherosclerosis progression.
Clin Transl Med
January 2025
Vascular Research Laboratory, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Background: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids and leukocytes within the arterial wall. By studying the aortic transcriptome of atherosclerosis-prone apolipoprotein E (ApoE) mice, we aimed to identify novel players in the progression of atherosclerosis.
Methods: RNA-Seq analysis was performed on aortas from ApoE and wild-type mice.
Relationship Between Carotid Artery Remodeling Characteristics and Early Carotid Atherosclerosis: An Ultrasonographic Multicenter Study.
J Ultrasound Med
January 2025
Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China.
Objectives: This study analyzed carotid artery remodeling characteristics in early carotid atherosclerosis (ECAS).
Methods: The 1021 participants were evaluated using ultrasonography and categorized into three groups: Group A, 391 participants with increased intima-media thickness (IMT); Group B, 300 participants with atherosclerotic plaque only on the carotid bulb (CB); and the control group (330 participants). The ratios of the diameters in the CB to those in the common carotid artery (D) and internal carotid artery (D) were defined as carotid index1 (CI) and 2 (CI).
The molecular mechanisms of cuproptosis and its relevance to atherosclerosis.
Biomol Biomed
January 2025
Department of Cardiovascular Medicine, Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
Atherosclerosis (AS) is a chronic inflammatory disease associated with lipid deposition in the vascular intima. Copper is a vital trace element implicated in the onset and progression of AS. Excessive intracellular copper accumulation induces a unique form of cell death termed "cuproptosis.
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