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Substance Use is Associated With College Students' Acute Parasympathetic Nervous System Responses to Challenge.
Stress Health
February 2025
Prevention Science Institute, University of Oregon, Eugene, Oregon, USA.
College students use substances for varied reasons, including to cope with stress. The parasympathetic nervous system (PNS) regulates bodily functions to promote energy conservation (the 'rest and digest' response), and individuals differ in their physiological sensitivity to challenge. It remains unclear whether greater PNS responses (i.
View Article and Find Full Text PDFSafety, Tolerability, and Pharmacokinetics of a Novel Anti-obesity Agent, S-309309, in Healthy Adults with or Without Obesity.
Clin Drug Investig
January 2025
Medical Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Background: Anti-obesity medications are recommended for patients who do not achieve and maintain weight loss despite lifestyle interventions. S-309309 is a novel oral inhibitor of monoacylglycerol O-acyltransferase 2 being developed as a treatment for obesity.
Objective: The objective of the study was to investigate the safety, clinical pharmacology, pharmacokinetics and pharmacodynamic biomarker of S-309309.
Key Concepts in Machine Learning and Clinical Applications in the Cardiac Intensive Care Unit.
Curr Cardiol Rep
January 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Purpose Of Review: Artificial Intelligence (AI) technology will significantly alter critical care cardiology, from our understanding of diseases to the way in which we communicate with patients and colleagues. We summarize the potential applications of AI in the cardiac intensive care unit (CICU) by reviewing current evidence, future developments and possible challenges.
Recent Findings: Machine Learning (ML) methods have been leveraged to improve interpretation and discover novel uses for diagnostic tests such as the ECG and echocardiograms.
Effects of Different Connection Modes of Electroacupuncture on Electrocardiogram and Nerve Discharge in Rats.
J Vis Exp
January 2025
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine;
Electroacupuncture (EA) is one of the most commonly used methods in acupuncture and has a good effect on pain, depression, sensory movement disorders, and other diseases. The effectiveness of EA is influenced by many factors, such as the accuracy of acupoint selection, the duration and course of EA treatment, and EA parameters. However, it has rarely been discussed whether the positive and negative electrodes of the EA instrument with acupoints at different locations and distances have an effect on the curative effect.
View Article and Find Full Text PDFBackground And Aims: Bendopnea is a symptom found in patients with heart failure (HF) defined as shortness of breath when bending forward. The present study examined the correlation between bendopnea with other cardiac symptoms, echocardiographic findings, and cardiac function parameters.
Methods: This was a single-center prospective cross-sectional study of patients diagnosed with systolic HF.
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