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Discrete phase model of blood flow in a roughness microchannel simulating the formation of pseudointima.
Acta Bioeng Biomech
January 2022
Institute of Metallurgy and Materials Science, Polish Academy of Sciences, Kraków, Poland.
Purpose: The goal of the present study was the development of discrete phase model to simulate the phenomenon of backfilling a morphologically complex surface by red blood cells (RBCs) in a flow microchannel and to anticipate the conditions of forming a pseudointima. The objective of the experimental studies that inspired the development of the simulation was to create a surface that stimulates the formation of the pseudointima layer.
Methods: The finite volume method (FVM) and discrete particle method (DPM) were applied to develop the target model.
A Novel Hybrid Silk Fibroin/Polyurethane Arteriovenous Graft for Hemodialysis: Proof-of-Concept Animal Study in an Ovine Model.
Adv Healthc Mater
October 2020
Department of Health, Animal Science and Food Safety, Università degli Studi di Milano, Milano, 20122, Italy.
To solve the problem of vascular access failure, a novel semi-degradable hybrid vascular graft, manufactured by electrospinning using silk fibroin and polyurethane (Silkothane), has been previously developed and characterized in vitro. This proof-of-concept animal study aims at evaluating the performances of Silkothane grafts in a sheep model of arteriovenous shunt, in terms of patency and short-term remodeling. Nine Silkothane grafts are implanted between the common carotid artery and the external jugular vein of nine sheep, examined by palpation three times per week, by echo-color Doppler every two weeks, and euthanized at 30, 60, and 90 days (N = 3 per group).
View Article and Find Full Text PDFThe development of a low-flow vascular prosthesis is a very topical issue. The authors present a pathway for the development of a prosthesis with optimal properties based on the idea of mimicking the characteristics of a biological model (saphenous vein graft) and programming these properties in the model of the prosthetic substitute. The vascular prosthesis presented consists of three layers - a non-absorbable scaffold representing vascular “media”, and two absorbable collagen layers - pseudointima and pseudoadventitia.
View Article and Find Full Text PDFIn vivo evaluation of an in-body, tissue-engineered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model.
J Artif Organs
June 2013
Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.
Using simple, safe, and economical in-body tissue engineering, autologous valved conduits (biovalves) with the sinus of Valsalva and without any artificial support materials were developed in animal recipients' bodies. In this study, the feasibility of the biovalve as an aortic valve was evaluated in a goat model. Biovalves were prepared by 2-month embedding of the molds, assembled using two types of specially designed plastic rods, in the dorsal subcutaneous spaces of goats.
View Article and Find Full Text PDFComparison of straight and Venaflo-type cuffed arteriovenous ePTFE grafts in an animal study.
J Vasc Surg
June 2011
Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University, Jena, Germany.
Background: The long-term prognosis of arteriovenous (AV) polytetrafluoroethylene (PTFE) hemodialysis grafts is dissatisfying. Responsible for the poor outcome is a stenosis of the venous anastomosis. This originates from both pseudointimal (PI) and neointimal hyperplasia (IH) development.
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