Background: Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion.
Methods: In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma.
Results: These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor.
Conclusions: These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.
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