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| http://dx.doi.org/10.1038/bjc.1963.26 | DOI Listing |
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Electrochemical capacitance-based aptasensor for HER2 detection.
Biomed Microdevices
January 2025
Department of Physics, Faculty of Philosophy, Science and Letter, University of São Paulo, Ribeirão Preto, SP, 14040-901, Brazil.
The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) protein is specifically related to tumor cell proliferation in breast cancers. Its presence in biological serum samples indicates presence or progression of cancer, becoming a promise biomarker. However, their detection needs a simple and high accuracy platform.
View Article and Find Full Text PDFDemographics and outcomes of acute type A aortic dissection in young adults in southeastern China: impact of syndromic heritable thoracic aortic disease.
Ann Med
December 2025
Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, PR China.
Background: This study aimed to investigate the demographics and to evaluate long-term outcomes of acute type A aortic dissection (ATAAD) in surgically treated patients ≤40 years in China.
Methods: This study included patients aged ≤40 with ATAAD who underwent surgical treatment at our institution between 2015 and 2019. The patients were categorized into groups according to heritable thoracic aortic disease (HTAD) presence or absence.
Deep Learning Superresolution for Simultaneous Multislice Parallel Imaging-Accelerated Knee MRI Using Arthroscopy Validation.
Radiology
January 2025
From the Department of Radiology, Division of Musculoskeletal Radiology, NYU Grossman School of Medicine, 660 1st Ave, 3rd Fl, Rm 313, New York, NY 10016 (S.S.W., J.V., R.K., E.H.P., J.F.); Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, University Hospital Tübingen, Tübingen, Germany (S.S.W.); Department of Radiology, University Hospital Basel, Basel, Switzerland (J.V.); Department of Radiology, Hospital do Coraçao, São Paulo, Brazil (T.C.R.); Academic Surgical Unit, South West London Elective Orthopaedic Centre (SWLEOC), London, United Kingdom (D.D.); Department of Radiology, Balgrist University Hospital, Zurich, Switzerland (B.F.); Department of Radiology, Jeonbuk National University Hospital, Jeonju, Republic of Korea (E.H.P.); Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea (E.H.P.); Medscanlagos Radiology, Cabo Frio, Brazil (A.S.); Centre for Data Analytics, Bond University, Gold Coast, Australia (S.E.S.); Siemens Healthineers AG, Erlangen, Germany (I.B.); and Siemens Medical Solutions USA, Malvern, Pa (G.K.).
Background Deep learning (DL) methods can improve accelerated MRI but require validation against an independent reference standard to ensure robustness and accuracy. Purpose To validate the diagnostic performance of twofold-simultaneous-multislice (SMSx2) twofold-parallel-imaging (PIx2)-accelerated DL superresolution MRI in the knee against conventional SMSx2-PIx2-accelerated MRI using arthroscopy as the reference standard. Materials and Methods Adults with painful knee conditions were prospectively enrolled from December 2021 to October 2022.
View Article and Find Full Text PDFPhase-based structured interrogation frequency-domain near-infrared spectroscopy.
J Opt Soc Am A Opt Image Sci Vis
August 2024
Frequency-domain near-infrared spectroscopy (FD-NIRS) is a noninvasive method for quantitatively measuring optical absorption and scattering in tissue. This study introduces structured interrogation (SI) as an interference-based approach for implementing FD-NIRS in order to enhance optical property estimation in multilayered tissues and sensitivity to deeper layers. We find that, in the presence of realistic noise, SI accurately estimates properties and chromophore concentrations with less than a 5% error.
View Article and Find Full Text PDFVacuolated Parabasal Cells in Papanicolaou Smears Are Cellular Changes Caused by Human Papillomavirus 16 Infection.
J Med Virol
February 2025
Department of Medical Technology, Faculty of Health Sciences, Kyorin University, Tokyo, Japan.
In cervical cancer screening, cytology is used as a triage test to refer high-risk human papillomavirus (HR-HPV)-positive women for colposcopy, but its accuracy is inadequate. The present study aimed to demonstrate that the presence of atypical cells with large vacuoles in the cytoplasm of parabasal cells, referred to as vacuolated parabasal cells (VPCs), which are observed in the Pap smears of HPV-positive women, is associated with specific HPV genotypes. Among 2175 patients, 310 with a single HR-HPV infection and cytological diagnosis of high-grade squamous intraepithelial lesions (HSIL) or atypical squamous cells not excluding HSIL (ASC-H) were included, of which 86 were infected with HPV16.
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