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Single-centre, randomised and double-blind clinical trial on the efficacy of transcutaneous auricular vagus nerve stimulation in preventing and treating primary headache in children and adolescents: a study protocol.
BMJ Open
March 2025
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Introduction: Primary headaches pose a significant burden on children and adolescents, highlighting the need for effective non-pharmacological interventions. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive modality that has demonstrated efficacy in adult populations with primary headaches and has shown safety in adolescents with mental health disorders. However, its effectiveness in managing acute headache episodes and preventing recurrences in paediatric populations remains underexplored.
View Article and Find Full Text PDFResveratrol reduces RVLM neuron activity via activating the AMPK/Sirt3 pathway in stress-induced hypertension.
J Biol Chem
March 2025
School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; School of Life Sciences, Shanghai University, Shanghai, China; College of Life Sciences, Dezhou University, Dezhou, Shandong, China; College of Agriculture and Bioengineering, Heze University, Heze, Shandong, China; Department of Preventive Medicine, Heze Medical College, Heze, Shandong, China; Shaoxing Institute of Shanghai University, Shaoxing, Zhejiang, China. Electronic address:
Neuronal hyperexcitability in the rostral ventrolateral medulla (RVLM), driven by oxidative stress, plays a crucial role in stress-induced hypertension (SIH). While resveratrol (RSV) is known for its antioxidant properties, its effects on RVLM neurons in SIH remain unclear. We investigated this using an SIH rat model exposed to electric foot shocks and noise stimulation for 15 days.
View Article and Find Full Text PDFExosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy.
Mech Ageing Dev
March 2025
Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati 781039, Assam, India. Electronic address:
Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated to developing effective therapeutics to target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit the cell cycle.
View Article and Find Full Text PDFEvaluating the reliability of geophysical methods for investigating the migration of a hydrocarbon plume: validation by sample analysis.
Environ Pollut
March 2025
Sumec Complete Equipment and Engineering Co., Ltd, Nanjing 210018, Jiangsu Province, China.
Geophysical methods are extensively used to assess contaminated sites. However, the validation of geophysical exploration results remains crucial for practical applications of these methods. In this study, Electrical Resistivity Tomography (ERT) and Ground Penetrating Radar (GPR) were used to investigate an abandoned hydrocarbon-contaminated site in Jiangsu, China.
View Article and Find Full Text PDF[Evaluation of the Deodorizing Effect of an Electric Scalpels with a Smoke Evacuation System in Breast Surgery].
Gan To Kagaku Ryoho
February 2025
Dept. of Breast Surgery, Niigata City General Hospital.
Exposure to surgical smoke can cause discomfort owing to its odor. Although electric scalpels with smoke evacuation systems are recommended to reduce exposure to surgical smoke, few reports have focused on its effectiveness in odor reduction. This study aimed to evaluate the deodorizing effects of an electric scalpel with a smoke evacuation system during breast surgery.
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