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New Polyhydroxysteroid Glycosides with Antioxidant Activity from the Far Eastern Sea Star .
Mar Drugs
November 2024
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
Article Synopsis
- * The new glycosides feature a common steroid core structure but differ in their sugar components, with ceramasterosides A and B being the first examples from starfish.
- * Biological tests showed these compounds exhibit antioxidant properties by reducing harmful substances in a model of inflammation, marking a significant discovery for their potential use in mitigating oxidative stress.
Epibrassinolide impaired colon tumor progression and induced autophagy in SCID mouse xenograft model via acting on cell cycle progression without affecting endoplasmic reticulum stress observed in vitro.
Int J Biochem Cell Biol
February 2023
Gebze Technical University, Institute of Biotechnology, 41400 Gebze, Kocaeli, Türkiye.
Epibrassinolide is a member of brassinosteroids with a polyhydroxysteroid structure similar to steroid hormones of vertebrates. It was shown that EBR decreased cell proliferation and induced apoptosis in different colon cancer cell lines without exerting a cytotoxic effect in epithelial fetal human colon cells. This finding highlighted the potential of epibrassinolide in clinical therapeutic setup.
View Article and Find Full Text PDFExcavation of Genes Responsive to Brassinosteroids by Transcriptome Sequencing in Gametophytes.
Genes (Basel)
June 2022
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Brassinosteroids (BRs) are a class of polyhydroxysteroid plant hormones; they play important roles in the development and stress resistance of plants. The research on BRs has mainly been carried out in angiosperms, but in ferns-research is still limited to the physiological level and is not in-depth. In this study, gametophytes were used as materials and treated with 10 M brassinolide (BL).
View Article and Find Full Text PDFApplication of MS-Based Metabolomic Approaches in Analysis of Starfish and Sea Cucumber Bioactive Compounds.
Mar Drugs
May 2022
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, 159 Prospect 100-let Vladivostoku, Vladivostok 690022, Russia.
Today, marine natural products are considered one of the main sources of compounds for drug development. Starfish and sea cucumbers are potential sources of natural products of pharmaceutical interest. Among their metabolites, polar steroids, triterpene glycosides, and polar lipids have attracted a great deal of attention; however, studying these compounds by conventional methods is challenging.
View Article and Find Full Text PDFSynthesis and Biological Activity of New Brassinosteroid Analogs of Type 24-Nor-5β-Cholane and 23-Benzoate Function in the Side Chain.
Int J Mol Sci
May 2021
Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, CP 2340000, Chile.
Brassinosteroids are polyhydroxysteroids that are involved in different plants' biological functions, such as growth, development and resistance to biotic and external stresses. Because of its low abundance in plants, much effort has been dedicated to the synthesis and characterization of brassinosteroids analogs. Herein, we report the synthesis of brassinosteroid 24-nor-5β-cholane type analogs with 23-benzoate function and 22,23-benzoate groups.
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