A computer program is described which allows analysis of reflex muscle responses to electric stimulation of peripheral nerves. Basically, the program is derived from an older methodic approach, yet the process of evaluating the obtained means of reflex muscle responses is in this computer assisted procedure simpler and of a higher quality. The proposed improvement of the original methodic approach provides an important advantage for clinical practice in significantly speeding up the investigation and evaluation of reflex muscle responses on using financially accessible computer technique of Czechoslovak make. The paper points out the possibility of using the program also for analysis of other biological signals and of adjusting it for more efficient types of personal computers.
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Environ Toxicol Chem
January 2025
Department of Pharmaceutical Technology, Faculty of Pharmacy, Atatürk University, Erzurum, Türkiye.
Epilepsy, the most common neurological disorder worldwide, is characterized by sudden paroxysmal brain activity, which can be generalized or focal. Extensive research has explored various treatment strategies for this condition. Our study employed a pilocarpine (PL)-induced seizure model in zebrafish (Danio rerio) embryos and larvae to assess the effects of carbamazepine (CBZ)-loaded chitosan-coated PLGA-Zein nanoparticles (NPs) over 96 hours.
View Article and Find Full Text PDFKnee Surg Sports Traumatol Arthrosc
January 2025
Department of Orthopaedic Surgery, Hôpital Pierre Paul Riquet, CHU de Toulouse, Toulouse, France.
Purpose: Arthrogenic muscle inhibition (AMI) is a reflexive shutdown of the quadriceps muscles following a knee injury or surgery that presents with or without hamstring contracture. This complication can be classified according to the SANTI classification, but the reproducibility of this clinical classification has not yet been demonstrated.
Methods: This single-centre longitudinal observational study included 140 patients who were within 6 weeks of an ACL rupture.
Exp Brain Res
January 2025
Ashton Graybiel Spatial Orientation Laboratory, Brandeis University, MS 033, 415 South Street, Waltham, MA, 02453, USA.
Younger adults (YA) and older adults (OA) used a joystick to stabilize an unstable visual inverted pendulum (VIP) with a fundamental frequency (.27 Hz) of half that of bipedal human sway. Their task was to keep the VIP upright and to avoid ± 60° "fall" boundaries.
View Article and Find Full Text PDFClin Exp Optom
January 2025
Department of Optometry, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Clinical Relevance: The vestibular-ocular reflex stabilises the retinal image and maintains balance during head movement. Astigmatism is one of the common refractive errors that can reduce the quality of visual inputs.
Background: The purpose of this study was to investigate the effect of induced astigmatism on the function of the vestibular-ocular reflex.
Wearable Technol
December 2024
Biorobotics Laboratory, EPFL, Lausanne, Vaud, Switzerland.
Neuromuscular controllers (NMCs) offer a promising approach to adaptive and task-invariant control of exoskeletons for walking assistance, leveraging the bioinspired models based on the peripheral nervous system. This article expands on our previous development of a novel structure for NMCs with modifications to the virtual muscle model and reflex modulation strategy. The modifications consist firstly of simplifications to the Hill-type virtual muscle model, resulting in a more straightforward formulation and reduced number of parameters; and second, using a finer division of gait subphases in the reflex modulation state machine, allowing for a higher degree of control over the shape of the assistive profile.
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