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Abolition of sagittal T7-T10 dynamics during forced ventilation in AIS patients with Lenke 1A curves.
Sci Rep
April 2023
Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, Quevedo, 2, 46001, Valencia, Spain.
In healthy subjects, respiratory maximal volumes are highly dependent on the sagittal range of motion of the T7-T10 segment. In AIS, the abolition of T7-T10 dynamics related to the stiffness induced by the apex region in Lenke IA curves could harm ventilation during maximal breathing. The aim of this study was to analyze the dynamics of the thoracic spine during deep breathing in AIS patients and in healthy matched controls.
View Article and Find Full Text PDFExosomal STIMATE derived from type II alveolar epithelial cells controls metabolic reprogramming of tissue-resident alveolar macrophages.
Theranostics
February 2023
School of Biological Sciences and Medical Engineering & Zhongda Hospital, School of Medicine, Advanced Institute for Life and Health & Interdisciplinary Innovation Institute for Medicine and Engineering, Southeast University, Nanjing, China.
Complete abolition of alveolar epithelial cells (AECs) is characteristic of end-stage lung disease. Transplantation therapy of type II AECs (AEC-IIs) or AEC-IIs-derived exosomes (ADEs) have been proposed as a means of repairing injury and preventing fibrosis. However, the mechanism by which ADEs balances airway immunity and alleviates damage and fibrosis remains unknown.
View Article and Find Full Text PDFOxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors.
Proc Natl Acad Sci U S A
September 2022
Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen del Rocío, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Seville, 41013 Spain.
Acute oxygen (O) sensing is essential for adaptation of organisms to hypoxic environments or medical conditions with restricted exchange of gases in the lung. The main acute O-sensing organ is the carotid body (CB), which contains neurosecretory chemoreceptor (glomus) cells innervated by sensory fibers whose activation by hypoxia elicits hyperventilation and increased cardiac output. Glomus cells have mitochondria with specialized metabolic and electron transport chain (ETC) properties.
View Article and Find Full Text PDFAcute O sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Sci Signal
January 2020
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville 41013, Spain.
Acute cardiorespiratory responses to O deficiency are essential for physiological homeostasis. The prototypical acute O-sensing organ is the carotid body, which contains glomus cells expressing K channels whose inhibition by hypoxia leads to transmitter release and activation of nerve fibers terminating in the brainstem respiratory center. The mechanism by which changes in O tension modulate ion channels has remained elusive.
View Article and Find Full Text PDFIntravenous magnesium sulphate infusion as first-line therapy in the control of spasms and muscular rigidity in childhood tetanus.
Paediatr Int Child Health
August 2019
c Department of Paediatrics , Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai , India.
: Reports suggest that, in tetanus, magnesium sulphate (MgSO) alone may control muscle spasms, thereby avoiding sedation and mechanical ventilation. : To study the efficacy and safety of intravenous MgSO in controlling spasms and rigidity in children with tetanus. : All children with tetanus consecutively admitted over a 2-year period in a tertiary-care teaching hospital were recruited.
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