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Concurrent exercise training potentiates the effects of angiotensin-converting enzyme inhibitor on regulatory systems of blood pressure control in ovariectomized hypertensive rats.
J Hypertens
April 2024
Exercise Physiology Laboratory, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Objective: Enalapril has shown satisfactory potential in controlling increased and sustained blood pressure (BP). However, multiple dysregulated mechanisms that interact with each other and are involved in the pathophysiology of arterial hypertension may not be affected, contributing to the remaining cardiovascular risk. Using an exercise training protocol, we investigated whether adding both approaches to arterial hypertension management could promote higher modulation of regulatory mechanisms of BP in postmenopausal rats.
View Article and Find Full Text PDFImpact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.
Neural Plast
November 2021
Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Article Synopsis
- Resiniferatoxin is a potent compound that can cause neuropathic pain and inflammatory responses, leading to the investigation of how blocking hepatoma-derived growth factor (HDGF) influences these effects.
- The study used male Sprague-Dawley rats, divided into groups, to analyze the impact of HDGF blockage on mechanical pain thresholds and neuronal changes through various assays, including ELISA and immunofluorescence.
- Results indicated that inhibiting HDGF improved pain responses, reduced inflammatory markers, and protected neuron cells in the spinal cord, suggesting that targeting HDGF might offer a new approach to pain relief beyond traditional painkillers.
Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood.
J Anal Methods Chem
October 2018
Laboratory Animal Centre, Wenzhou Medical University, Wenzhou 325035, China.
Delsoline, a major alkaloid of Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. A ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established for the determination of delsoline in mouse blood, and the pharmacokinetics of delsoline after intravenous administration (1 mg/kg) and intragastric administration (9, 6, and 3 mg/kg) were studied. Gelsenicine served as an internal standard, and a UPLC BEH C18 chromatographic column was used.
View Article and Find Full Text PDFElevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects.
Cardiovasc Res
April 2018
Department of Physiology, University of Tennessee Health Sciences Center, 71 South Manassas Street, Memphis, TN 38163, USA.
Aims: Stromal interaction molecule 1 (STIM1) has emerged as an important player in the regulation of growth and proliferation of smooth muscle cells. Therefore, we hypothesized that STIM1 plays a crucial role in the maintenance of vascular integrity. The objective of this study was to evaluate whether reduced expression of STIM1 could modify the structure and function of the vasculature, leading to changes in blood pressure (BP).
View Article and Find Full Text PDFUltrasound-guided high-thoracic paravertebral block relieves referred pain caused by cervical spondylosis and provides stellate ganglion-blocking effect.
J Clin Anesth
November 2016
Department of Anesthesiology and Critical Care, Ehime Prefectural Central Hospital, Matsuyama City, Ehime 790-0024, Japan.
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