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Aberrant Cortical Morphological Networks in First-Episode Schizophrenia.
Schizophr Bull
January 2025
Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China.
Background And Hypothesis: Population-based morphological covariance networks are widely reported to be altered in schizophrenia. Individualized morphological brain network approaches have emerged recently. We hypothesize that individualized morphological brain networks are disrupted in schizophrenia.
View Article and Find Full Text PDFCausal associations between hypertension and abnormal brain cortical structures: Insights from a bidirectional Mendelian randomization study.
Int J Cardiol Cardiovasc Risk Prev
March 2025
Department of Cardiology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Background: Observational studies suggest that hypertension affects brain cortical structure. However, the potential causal association has yet to be entirely determined. Thus, we aim to assess the causality between hypertension and abnormal cortical structure.
View Article and Find Full Text PDFPredicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group.
Hum Brain Mapp
January 2025
Amsterdam UMC, Department of Radiology and Nuclear Medicine, University of Amsterdam, Amsterdam, the Netherlands.
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that predict individual-level pharmacotherapeutic treatment response using cortical morphometry from multisite longitudinal cohorts. We conducted an international analysis of pooled data from six sites of the ENIGMA-MDD consortium (n = 262 MDD patients; age = 36.
View Article and Find Full Text PDFFinite Element Model of Patient-Specific Flanged Acetabular Components Highlights Biomechanical Effects of Bone Density and Cortical Shell Thickness.
J Orthop Res
January 2025
Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, New York, USA.
Patient-specific flanged acetabular components are utilized to treat failed total hip arthroplasties with severe acetabular defects. We previously developed and published a finite element model that investigated the impact of hip joint center lateralization on construct biomechanics during gait conditions. This model consisted of a patient-specific implant designed to address a superior-medial defect created in a standard pelvic geometry.
View Article and Find Full Text PDFDisentangling the effect of sex from brain size on brain organization and cognitive functioning.
Geroscience
January 2025
Cerebral Imaging Center, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montréal, QC, H4H 1R3, Canada.
Neuroanatomical sex differences estimated in neuroimaging studies are confounded by total intracranial volume (TIV) as a major biological factor. Employing a matching approach widely used for causal modeling, we disentangled the effect of TIV from sex to study sex-differentiated brain aging trajectories, their relation to functional networks and cytoarchitectonic classes, brain allometry, and cognition. Using data from the UK Biobank, we created subsamples that removed, maintained, or exaggerated the TIV differences in the original sample.
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