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Validated HPLC-UV Method for the Quantification of a Novel BCr-Abl 1 Inhibitor, Vodobatinib, in Rat Plasma: Application to a Pharmacokinetic Study.
Biomed Chromatogr
February 2025
Drug Metabolism and Pharmacokinetics, Laxai Life Sciences Pvt. Ltd., Shamirpet, Hyderabad, India.
Vodobatinib is a Bcr-Abl 1 inhibitor, currently entering into Phase 2 clinical trials as a potential drug to treat glioblastoma patients. In the present work, a validated high-performance liquid chromatography (HPLC) detection method for the quantification of vodobatinib in rat plasma was established. Sample preparation involved liquid-liquid extraction method.
View Article and Find Full Text PDFGenomic Analysis of Carbapenem-Resistant Isolated from Bloodstream Infections in South Korea.
Antibiotics (Basel)
November 2024
Division of Antimicrobial Resistance Research, National Institute of Health, Korea Disease Control and Prevention Agency, 187 Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si 28159, Republic of Korea.
Background/objectives: Bloodstream infection by carbapenem-resistant (CRAB) is a serious clinical problem worldwide. To study its clonal relationship and genetic features, we report the draft genome sequence of CRAB strains isolated from human blood in South Korea.
Methods: Among strains isolated from patients at nine general hospitals in 2020, 12 CRAB strains of different genotypes were selected.
Neutrophil Extracellular Traps Drive Kidney Stone Formation.
Kidney Dis (Basel)
November 2024
Department of Geriatric Urology, Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha, PR China.
Introduction: This study aims to explore the contribution of neutrophil extracellular traps (NETs) to kidney stones.
Methods: The microarray data from GSE73680 and bioinformatic analysis were applied to identify differentially expressed genes in patients with kidney stones. A rat model of kidney stones was established through ethylene glycol and ammonium chloride administration.
Targeted delivery strategy of indocyanine green-mitoxantrone loaded liposomes co-modified with BTP-7 and BR2 for the treatment of glioma.
Pharm Dev Technol
January 2025
Guangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning, China.
Article Synopsis
- The study focuses on creating a new drug delivery system using dual-ligand-modified liposomes to target glioma, with the goal of overcoming the blood-brain barrier and improving drug effectiveness.
- Researchers used a specific technique to prepare liposomes that co-load a photosensitizer (ICG) and a chemotherapeutic drug (MTO), and tested their properties and ability to penetrate the blood-brain barrier while targeting glioma cells.
- Results showed that the modified liposomes were stable, capable of effectively penetrating the blood-brain barrier, concentrating in glioma cells, and exhibited strong anti-tumor effects, highlighting their potential in improving glioma treatment.
Survival after aluminum phosphide poisoning with cardiotoxicity: a case report.
J Med Case Rep
December 2024
Department of Internal Medicine, Woldia Comprehensive Specialized Hospital, Woldia, Ethiopia.
Introduction: Aluminum phosphide is a cheap and commonly used rodenticide that is also an effective solid fumigant and frequently used for grain preservation. The pill contains around 44% inert elements (ammonium carbonate) to avoid disintegration of the tablet, while the rest (about 56%) is aluminum phosphide. Because it is freely available on the market, it is one of the commonly used agents for self-poisoning in different parts of the developing world.
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