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Prediction of gene expression using histone modification patterns extracted by Particle Swarm Optimization.
Bioinformatics
January 2025
Department of Medical Bioinformatics, University Medical Center Göttingen, Göttingen, 37099, Germany.
Motivation: Histone modifications play an important role in transcription regulation. Although the general importance of some histone modifications for transcription regulation has been previously established, the relevance of others and their interaction is subject to ongoing research. By training Machine Learning models to predict a gene's expression and explaining their decision making process, we can get hints on how histone modifications affect transcription.
View Article and Find Full Text PDFCoupling of Size Exclusion Chromatography to High Throughput Charge Detection Mass Spectrometry for the Analysis of Large Proteins and Virus-like Particles.
Anal Chem
January 2025
Chemistry Department, Indiana University, Bloomington, Indiana 47405, United States.
Charge detection mass spectrometry (CD-MS) is an emerging single-particle technique where both the / and charge are measured individually to determine each ion's mass. It is particularly well-suited for analyzing high mass and heterogeneous samples. With conventional MS, the loss of charge state resolution with high mass samples has hindered the direct coupling of MS to separation techniques like size exclusion chromatography (SEC) and forced the use of lower resolution detectors.
View Article and Find Full Text PDFBackground: Radiomics provides quantitative features of pulmonary nodules (PNs) which could aid lung cancer diagnosis, but medical image acquisition variability is an obstacle to clinical application. Acquisition effects may differ between radiomic features from benign vs. malignant PNs.
View Article and Find Full Text PDFEfficacy of plant extracts against the immature stage of house fly, Musca domestica (Diptera: Muscidae).
Trop Biomed
December 2024
Department of Entomology and Plant Pathology, Khon Kaen University, Thailand Mittapap Road, Khon Kaen, Khon Kaen, 40002, Thailand.
This research aimed to find indigenous plants and suitable solvents to extract substances with the capacity to suppress the immature stages of house fly populations in animal farms and urban areas. Seven native Thai plants were tested: Alstonia scholaris (L.) R.
View Article and Find Full Text PDFA key contribution to X-ray dark-field (XDF) contrast is the diffusion of X-rays by sample structures smaller than the imaging system's spatial resolution; this is related to position-dependent small-angle X-ray scattering. However, some experimental XDF techniques have reported that XDF contrast is also generated by resolvable sample edges. Speckle-based X-ray imaging (SBXI) extracts the XDF by analyzing sample-imposed changes to a reference speckle pattern's visibility.
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