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Characteristics and survival outcomes in pediatric patients with spinal chordomas: insights from the National Cancer Database and review of the literature.
J Neurooncol
January 2025
Departments of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Purpose: Spinal chordomas are aggressive tumors that rarely occur in the pediatric population. Demographics and post-treatment outcomes in this select group of patients is poorly studied. We hence aimed to analyze the clinical characteristics, demographics, and survival outcomes of pediatric patients with spinal chordomas, in contrast to the adult population.
View Article and Find Full Text PDFExtracellular Vesicles from a Novel Chordoma Cell Line, ARF-8, Promote Tumorigenic Microenvironmental Changes When Incubated with the Parental Cells and with Human Osteoblasts.
Int J Mol Sci
November 2024
Department of Neurosurgery, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Chordomas are rare, generally slow-growing spinal tumors that nonetheless exhibit progressive characteristics over time, leading to malignant phenotypes and high recurrence rates, despite maximal therapeutic interventions. The tumors are notoriously resistant to therapies and are often located in regions that complicate achieving gross total resections. Cell lines from these tumors are rare as well.
View Article and Find Full Text PDFIsolated Sphenoid Fungal Sinusitis With Mucocele Mistaken for Chordoma: A Study of Two Unique Cases.
J Rhinol
March 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
Isolated sphenoid fungal sinusitis (ISFS) is a rare condition characterized by fungal infection of the sphenoid sinus. It often presents with non-specific symptoms, which can lead to misdiagnosis. This study presents two unique cases of ISFS with mucocele that were initially misdiagnosed as chordoma based on preoperative radiographic findings.
View Article and Find Full Text PDFExtraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization.
Mod Pathol
November 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:
Article Synopsis
- In a study of six EAPDC cases, histological features were similar to axial PDC, showing malignant cell characteristics, and genetic analysis revealed common loss of the SMARCB1 gene.
- Follow-up revealed significant clinical challenges, including local recurrences and metastasis within months of surgery, highlighting the aggressive nature and poor prognosis of these rare tumors.
Extra-Axial Poorly Differentiated Chordoma Initially Misdiagnosed as Epithelioid Sarcoma.
Int J Surg Pathol
November 2024
Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Article Synopsis
- Poorly differentiated chordoma is a rare and aggressive type of tumor usually found in young patients, mainly at the skull base and cervical spine.
- A case study of a 60-year-old patient initially misdiagnosed with osteoarthritis revealed complex tumor characteristics that led to reconsideration of its diagnosis.
- The importance of accurate immunohistochemical testing, specifically for brachyury, is emphasized for correctly diagnosing this uncommon tumor and for understanding its unique molecular profile, which could aid in future analyses.
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