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An accurate IDMS-based method for absolute quantification of phytohemagglutinin, a major antinutritional component in common bean.
J Food Sci
January 2025
Key Laboratory of Specialty Agri-Product Quality and Hazard Controlling Technology of Zhejiang, College of Life Sciences, China Jiliang University, Hangzhou, P.R. China.
Phytohemagglutinin (PHA), a natural tetramer comprising PHA-E and PHA-L subunits that preferentially bind to red and white blood cells, respectively, constitutes a significant antinutritional and allergenic factor in common bean seeds. The accurate measurement of PHA content is a prerequisite for ensuring food safety inspections and facilitating genetic improvements in common bean cultivars with reduced PHA levels. Currently, mainstream methods for PHA quantification involve hemagglutination assays and immunodetection, but these methods often require fresh animal blood and lack specificity and accuracy.
View Article and Find Full Text PDFTrivalent oleanolic acid-glucose conjugates: Synthesis and efficacy against Influenza A virus.
Eur J Med Chem
December 2024
School of Medicine, Kunming University of Science and Technology, Yunnan, 650500, China. Electronic address:
Article Synopsis
- Influenza A virus (IAV) causes serious health issues during seasonal outbreaks, leading to significant illness and death.
- Researchers synthesized oleanolic acid (OA) glucose trimers that effectively block IAV from interacting with host cells, demonstrating strong anti-viral activity, especially compounds 13a and 13b which outperformed the known treatment, oseltamivir.
- The study reveals that these new compounds may prevent the virus from entering host cells by disrupting the interaction between the virus's HA protein and sialic acid receptors, paving the way for future antiviral drug development using these natural products.
Receptor Binding Specificity of a Bovine A(H5N1) Influenza Virus.
bioRxiv
July 2024
Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Rd, Athens, GA 30602, USA.
Outbreaks in the US of highly pathogenic avian influenza virus (H5N1) in dairy cows have been occurring for months creating new possibilities for direct contact between the virus and humans. Eisfeld examined the pathogenicity and transmissibility of a bovine HPAI H5N1 virus isolated from New Mexico in a series of and assays. They found the virus has a dual human- and avian virus-like receptor-binding specificity as measured in a solid phase glycan binding assay.
View Article and Find Full Text PDFNovel sialidase inhibitors suppress mumps virus replication and infection.
Glycobiology
September 2024
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
The prevalent human pathogen, mumps virus (MuV; orthorubulavirus parotitidis) causes various complications and serious sequelae, such as meningitis, encephalitis, deafness, and impaired fertility. Direct-acting antivirals (DAAs) targeting MuV which can prevent mumps and mumps-associated complications and sequelae are yet to be developed. Paramyxoviridae family members, such as MuV, possess viral surface hemagglutinin-neuraminidase (HN) protein with sialidase activity which facilitates efficient viral replication.
View Article and Find Full Text PDFChemoenzymatic synthesis of sialyl-α2,3-lactoside-functionalized BSA conjugate inhibits influenza infection.
Eur J Med Chem
October 2024
China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, No. 29, 13th Avenue, TEDA, Tianjin, 300457, China. Electronic address:
Influenza remains a global public health threat, and the development of new antivirals is crucial to combat emerging drug-resistant influenza strains. In this study, we report the synthesis and evaluation of a sialyl lactosyl (TS)-bovine serum albumin (BSA) conjugate as a potential multivalent inhibitor of the influenza virus. The key trisaccharide component, TS, was efficiently prepared via a chemoenzymatic approach, followed by conjugation to dibenzocyclooctyne-modified BSA via a strain-promoted azide-alkyne cycloaddition reaction.
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