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The Redox Process in Red Blood Cells: Balancing Oxidants and Antioxidants.
Antioxidants (Basel)
December 2024
Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem P.O. Box 20002, Palestine.
Red blood cells (RBCs) are a vital component of the body's oxygen supply system. In addition to being pro-oxidants, they are also essential components of the body's antioxidant defense mechanism. RBCs are susceptible to both endogenous and exogenous sources of oxidants.
View Article and Find Full Text PDFThe role of tetrahydroxyquinone solubility on apoptosis induction in human colorectal cells.
Toxicol Mech Methods
January 2025
Cell Biology Laboratory, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico.
Tetrahydroxy-1,4-benzoquinone (THQ) is a highly redox-active substance that generates reactive oxygen species (ROS), which can induce apoptosis in cell culture experiments. The underlying mechanism for ROS production has previously been postulated to be the autoxidation of THQ to rhodizonic acid (RhA). However, our results suggest that the cells detoxify THQ by reducing it to hexahydroxybenzene (HHB), catalyzed by the NADPH-quinone-oxidoreductase (NQO1).
View Article and Find Full Text PDFThe mechanism of autoreduction in Dehaloperoxidase-A.
Biochem Biophys Res Commun
January 2025
Department of Chemistry, North Carolina State University, Raleigh, NC, 27695, USA. Electronic address:
Hemoglobin and myoglobin are known to undergo autoxidation, in which the oxyferrous form of the heme is oxidized to the ferric state by O. Dehaloperoxidase-A (DHP-A), a multifunctional catalytic hemoglobin from Amphitrite ornata is an exception and is observed to undergo the reverse process, during which the ferric heme is spontaneously reduced to the oxyferrous form under aerobic conditions. The high reduction potential of DHP (+202 mV at pH 7.
View Article and Find Full Text PDFNavigating the complexity of lipid oxidation and antioxidation: A review of evaluation methods and emerging approaches.
Prog Lipid Res
December 2024
CIRAD, UMR QualiSud, F-34398 Montpellier, France; Qualisud, Univ Montpellier, Avignon Université, CIRAD, Institut Agro, IRD, Université de la Réunion, Montpellier, France. Electronic address:
Lipid oxidative degradation contributes to the deterioration of food quality and poses potential health risks. A promising approach to counteract this is the use of plant-based antioxidants. However, accurately evaluating the antioxidant capacity and effectiveness of these compounds remains a challenge.
View Article and Find Full Text PDFThe Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.
Chem Rev
January 2025
Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm SE-171 77, Sweden.
The octadecanoids are a broad class of lipids consisting of the oxygenated products of 18-carbon fatty acids. Originally referring to production of the phytohormone jasmonic acid, the octadecanoid pathway has been expanded to include products of all 18-carbon fatty acids. Octadecanoids are formed biosynthetically in mammals via cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) activity, as well as nonenzymatically by photo- and autoxidation mechanisms.
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