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Ultrasound-assisted efficient targeting of doxorubicin to the tumor microenvironment by lyso-thermosensitive liposomes of varying phase transition temperatures.
Eur J Pharm Sci
January 2025
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Premature drug release is the primary hindrance to the effective function of the lyso-thermosensitive liposomes (LTSLs) of doxorubicin (Dox), known as ThermoDox® for the treatment of cancer. Herein, we have optimized LTSLs by using a combination of phospholipids (PLs) with high transition temperatures (Tm) to improve the therapeutic outcome in an assisted ultrasound approach. For this, several Dox LTSLs were prepared using the remote loading method at varying molar ratios (0 to 90%) of DPPC (Tm 41°C) and HSPC (Tm 54.
View Article and Find Full Text PDFInfluence of Monomer Size on CO Adsorption and Mechanical Properties in Microporous Cyanate Ester Resins.
Polymers (Basel)
January 2025
Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Molecular simulations offer valuable insights into thermosetting polymers' microstructures and interactions with small molecules, aiding in the development of advanced materials. In this study, we design two cyanate resin models featuring monomers of different sizes and employ a previously developed method to generate crosslinked structures. We then analyze their crosslinking processes and physicochemical properties.
View Article and Find Full Text PDFSustainable CO Capture: N,S-Codoped Porous Carbons Derived from Petroleum Coke with High Selectivity and Stability.
Molecules
January 2025
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua 321004, China.
CO capture from the flue gas is a promising approach to mitigate global warming. However, regulating the carbon-based adsorbent in terms of textural and surface modification is still a challenge. To overcome this issue, the present study depicts the development of cost-effective and high-performance CO adsorbents derived from petroleum coke, an industrial by-product, using a two-step process involving thiourea modification and KOH activation.
View Article and Find Full Text PDFComputational Fluid Dynamics as a Digital Tool for Enhancing Safety Uptake in Advanced Manufacturing Environments Within a Safe-by-Design Strategy.
Materials (Basel)
January 2025
Innovation in Research & Engineering Solutions (IRES), 1000 Brussels, Belgium.
In modern manufacturing environments, pollution management is critical as exposure to harmful substances can cause serious health issues. This study presents a two-stage computational fluid dynamic (CFD) model to estimate the distribution of pollutants in indoor production spaces. In the first stage, the Reynolds-averaged Navier-Stokes (RANS) method was used to simulate airflow and temperature.
View Article and Find Full Text PDFGut microbiomes are largely unchanged when exposed to their amphibian host's latitudinally variable upper thermal limit.
Comp Biochem Physiol A Mol Integr Physiol
January 2025
University of Connecticut, Department of Ecology and Evolutionary Biology, 75 North Eagleville Road, Storrs, CT 06269, United States of America.
Climate change will increase the frequency and severity of temperature extremes. Links between host thermal physiology and their gut microbiota suggest that organisms' responses to future climates may be mediated by their microbiomes, raising the question of how the thermal environment influences the microbiome itself. Vertebrate gut microbiomes influence the physiological plasticity of their hosts via effects on immunity, metabolism, and nutrient uptake.
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