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Endothelial Reactive Oxygen Species: Key Players in Cardiovascular Health and Disease.
Antioxid Redox Signal
September 2024
Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Endothelial cells (ECs) line the entire vasculature system and serve as both barriers and facilitators of intra- and interorgan communication. Positioned to rapidly sense internal and external stressors, ECs dynamically adjust their functionality. Endothelial dysfunction occurs when the ability of ECs to react to stressors is impaired, which precedes many cardiovascular diseases (CVDs).
View Article and Find Full Text PDFEvolutionary adaptation of the protein folding pathway for secretability.
EMBO J
December 2022
Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Bacteriology, KU Leuven, Leuven, Belgium.
Secretory preproteins of the Sec pathway are targeted post-translationally and cross cellular membranes through translocases. During cytoplasmic transit, mature domains remain non-folded for translocase recognition/translocation. After translocation and signal peptide cleavage, mature domains fold to native states in the bacterial periplasm or traffic further.
View Article and Find Full Text PDFReal-Time Imaging and Quantification of Peptide Uptake and .
ACS Chem Biol
October 2019
Laboratory of Bioorganic Chemistry and Molecular Imaging, Institute of Chemical Sciences and Engineering (ISIC) , Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne , Switzerland.
Article Synopsis
- Peptides are crucial in treating various diseases, but many fail in clinical trials due to poor membrane permeability.
- Current methods to assess peptide permeability are limited and often require complex modifications that complicate the process.
- The new "Split Luciferin Peptide" (SLP) assay allows real-time, noninvasive imaging of peptide uptake, making it a valuable tool for preclinical studies.
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