Dispersions of fluorocarbons (PFC's) made with phospholipids have unusual properties, e.g. very high stability, due to the formation of thermodynamically stable vesicles. They can be used for high PFC concentrations as well as e.g. for ESR imaging.
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Asymmetrical calcium ions induced stress and remodeling in lipid bilayer membranes.
Phys Chem Chem Phys
January 2025
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Ca ions play crucial roles in regulating many chemical and biological processes, but their impact on lipid bilayer membranes remains elusive, especially when the impacts on the two leaflets are asymmetrical. Using a recently developed multisite Ca model, we performed molecular dynamics simulations to study the impact of Ca on the properties of membranes composed of POPC and POPS and observed that both the structure and fluidity of the membranes were significantly affected. In particular, we examined the influence of asymmetrically distributed Ca on asymmetric lipid bilayers and found that imbalanced stress in the two leaflets was generated, with the negatively charged leaflet on the Ca-rich side becoming more condensed, which in turn induced membrane curvature that bent the membrane away from the Ca-rich side.
View Article and Find Full Text PDFInsight into the outer membrane asymmetry of and the role of MlaA in modulating the lipidic composition, mechanical, biophysical, and functional membrane properties of the cell envelope.
Microbiol Spectr
November 2024
UCLouvain, Louvain Drug Research Institute, Cellular & Molecular Pharmacology, Brussels, Belgium.
Article Synopsis
- - In Gram-negative bacteria, the outer membrane has a unique structure, featuring lipopolysaccharides (LPS) on the outside and glycerophospholipids (GPLs) on the inside, with the Mla system maintaining this balance by removing misplaced GPLs from the outer layer.
- - The study examines how deleting certain components affects the lipid makeup of the bacteria, changing properties like membrane stiffness and antibiotic susceptibility, while noting an overall increase in GPLs and alterations in LPS structure.
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Formulation and Evaluation of a Transferosomal Gel of Famciclovir for Transdermal Use.
Turk J Pharm Sci
September 2024
Al Ameen College of Pharmacy, Department of Pharmacology, Bengaluru, India.
Objectives: Famciclovir, the drug of choice for cold sores and recurrent genital herpes, has poor oral bioavailability and is associated with numerous side effects. The study aimed to explore the possibility of transdermal application of famciclovir through a transferosome-loaded gelling system to localize the drug at the site of application with improved penetrability, therapeutic effects, and comfort.
Materials And Methods: Transferosomes of famciclovir were prepared using tween 80, phospholipid, and cholesterol.
Biomimetic Vesicles with Designer Phospholipids Can Sense Environmental Redox Cues.
JACS Au
May 2024
Department of Chemistry and Chemical Biology, Rutgers University, New Brunswick, New Jersey 08854, United States.
Cell-like materials that sense environmental cues can serve as next-generation biosensors and help advance the understanding of intercellular communication. Currently, bottom-up engineering of protocell models from molecular building blocks remains a grand challenge chemists face. Herein, we describe giant unilamellar vesicles (GUVs) with biomimetic lipid membranes capable of sensing environmental redox cues.
View Article and Find Full Text PDFIntravesicular Solute Delivery and Surface Area Regulation in Giant Unilamellar Vesicles Driven by Cycles of Osmotic Stresses.
J Am Chem Soc
February 2024
Department of Materials Science and Engineering, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Phospholipid bilayers are dynamic cellular components that undergo constant changes in their topology, facilitating a broad diversity of physiological functions including endo- and exocytosis, cell division, and intracellular trafficking. These shape transformations consume energy, supplied invariably by the activity of proteins. Here, we show that cycles of oppositely directed osmotic stresses─unassisted by any protein activity─can induce well-defined remodeling of giant unilamellar vesicles, minimally recapitulating the phenomenologies of surface area homeostasis and macropinocytosis.
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