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In vivo systemic evaluation of nasal drug absorption from powder formulations in rats.
Eur J Pharm Biopharm
February 2025
Laboratory of Pharmaceutical Technology, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe, Hyogo 658-8558, Japan.
Despite the potential benefits of nasal drug delivery, there is a need for a systematic evaluation of the efficacy of powder formulations adhering to the nasal mucosa. This study aims to establish a systematic evaluation method for nasal drug absorption from powder formulations. We selected three model compounds-antipyrine, griseofulvin, and acyclovir-and analyzed their pharmacokinetics following nasal administration of powder formulations under physiological conditions.
View Article and Find Full Text PDFIsolation of methyl caffeate and flacourtin from with comprehensive and pharmacological evaluation.
Heliyon
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
Article Synopsis
- The Indian Coffee Plum (Flacourtia jangomas) is a medicinal plant known for its bioactive compounds and potential therapeutic benefits, prompting research into its extracts from bark for medical applications.
- The study involved extracting phytochemicals using methanol, conducting screenings, and comparing the biological activities of the extracts, revealing the presence of new compounds like methyl caffeate and flacourtin.
- Results showed the extract has strong antioxidant and cytotoxic properties, pain relief effects, and moderate thrombolytic action, but limited antibacterial and antifungal activities, indicating a need for further research on its bioactive compounds.
Mechanisms of drug release from a melt-milled, poorly soluble drug substance.
J Pharm Sci
January 2025
TU Dortmund, Department of Biochemical and Chemical Engineering, Laboratory of Solids Process Engineering, Emil-Figge-Str. 68, 44227 Dortmund, Germany. Electronic address:
Increasing the dissolution kinetics of low aqueous soluble drugs is one of the main priorities in drug formulation. New strategies must be developed, which should consider the two main dissolution mechanisms: surface reaction and diffusion. One promising tool is the so-called solid crystal suspension, a solid dispersion consisting of purely crystalline substances.
View Article and Find Full Text PDFAssessing processability of milled HME extrudates: Consolidating the effect of extrusion temperature, drug loading, and particle size via Non-dimensional cohesion.
Int J Pharm
December 2024
New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, Newark, NJ 07102, USA. Electronic address:
The downstream processability of Hot Melt Extrusion (HME) Amorphous Solid Dispersions (ASD), an underexplored topic of importance, was assessed through a multi-faceted particle engineering approach. Extrudates, comprised of griseofulvin (GF), a model poorly water-soluble drug, and hydroxypropyl cellulose (HPC), were prepared at four drug concentrations and three HME temperature profiles to yield cases with and without residual crystallinity and subsequently milled to five sieve cuts ranging from < 45 μm to 355 - 500 μm. Solid state characterization was performed with XRPD, FT-IR, and TGA.
View Article and Find Full Text PDFExploring the preparation of griseofulvin CAMS with amino acids of different hydrophobicity as co-formers using a modified hot-melt extrusion process.
Int J Pharm
December 2024
Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 544 54 Thessaloniki, Greece. Electronic address:
Article Synopsis
- * The study evaluated the co-formability and stability of these systems through various analytical techniques, such as thermal analysis and crystallography.
- * Results showed that while CAMS with more hydrophobic amino acids had better supersaturation and stability in dissolution tests, the hydrophilic LYSinhibited dissolution performance, which improved with the use of a wetting agent.
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