Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1926124 | PMC |
| http://dx.doi.org/10.1136/bmj.2.5307.764 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial.
Trials
January 2025
Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.
Background: Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents. Compelling evidence has shown that such a population has a greater risk of cardiovascular events as well as mortality. Although mineralocorticoid receptor antagonists (MRAs) have been shown to be an effective fourth-line treatment for RH, a significant proportion of RH patients do not achieve their blood pressure target.
View Article and Find Full Text PDFRiboflavin overproduction from diverse feedstocks with engineered.
Biofabrication
July 2024
Department of Biotechnology and Food Science, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Riboflavin overproduction bywas achieved by screening synthetic operons, enabling fine-tuned expression of the riboflavin biosynthetic genesThe synthetic operons were designed by means of predicted translational initiation rates of each open reading frame, with the best-performing selection enabling riboflavin overproduction without negatively affecting cell growth. Overexpression of the fructose-1,6-bisphosphatase () and 5-phosphoribosyl 1-pyrophosphate aminotransferase () encoding genes was then done to redirect the metabolic flux towards the riboflavin precursors. The resulting strain produced 8.
View Article and Find Full Text PDFCombined eutexia and amorphization for simultaneous enhancement of dissolution rate of triamterene and hydrochlorothiazide: preparation of orodispersible tablets.
Drug Dev Ind Pharm
April 2024
Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Background: Triamterene is an oral antihypertensive drug with dissolution-limited poor bioavailability. It can be used as monotherapy or in fixed dose combination with hydrochlorothiazide which also suffers from poor dissolution. Moreover, co-processing of drugs in fixed dose combination can alter their properties.
View Article and Find Full Text PDFAcetazolamide for acute kidney injury in patients undergoing high dose methotrexate therapy: a systematic review and meta-analysis.
J Nephrol
May 2024
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN, USA.
Background: Urine alkalization is one of the standard treatments to prevent acute kidney injury in patients receiving high-dose methotrexate. Carbonic anhydrase inhibitors are promising adjuvants/substitutes with advantages such as faster urine alkalization time and prevention of fluid overload. However, there is limited and contradictory evidence on its efficacy and safety.
View Article and Find Full Text PDFSevere methotrexate toxicity in elderly patients under diuretics.
RMD Open
January 2024
Department of Medicine III and interdisciplinary University Centre for Autoimmune and Rheumatic Entities (UCARE), University Medical Centre and Faculty of Medicine TU Dresden, Dresden, Germany
Objectives: To explore the toxicity of low-dose methotrexate (MTX), an uncommon, but life-threatening event.
Methods: We analysed the presentation, course and risk factors of all patients admitted to the rheumatology ward with severe low-dose MTX toxicity. These patients were compared with patients without signs of relevant MTX toxicity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!