AI Article Synopsis
- In a study of 16 normal and pathological pregnancies, researchers administered a DHEA-S loading test via intravenous injection.
- The results showed a continuous increase in estradiol levels, peaking 60 minutes post-injection, though this increase was notably lower in pre-eclamptic patients and those with intrauterine growth retardation.
- No significant changes in estriol levels were detected within 3 hours following the injection, indicating different responses to the DHEA-S test in unhealthy pregnancies.
Article Abstract
In 16 normal and pathologic pregnancies we carried out the dehydroepiandrosterone-sulphate loading test by injection of 50 mg DHEA-S-Na intravenously. The plasma concentrations of unconjugated estradiol and estriol were measured by radioimmun-assay. The level of estradiol increased continuously, rising to a maximum 60 min after the injection. In pre-eclamptic patients and cases of intrauterine growth retardation the rise was significantly reduced. There was a good correlation between result of the test and clinical dates. In plasma concentrations of unconjugated estriol no changes could be observed within 3 hours after the injection.
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