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| http://dx.doi.org/10.1136/bjo.76.4.255 | DOI Listing |
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Similarities and distinctions in the activation of the Pdr1 regulatory pathway by azole and non-azole drugs.
mSphere
December 2024
Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Unlabelled: Incidences of fluconazole (FLC) resistance among clinical isolates are a growing issue in clinics. The pleiotropic drug response network in confers azole resistance and is defined primarily by the ZnCys zinc cluster-containing transcription factor Pdr1 and target genes such as , which encodes an ATP-binding cassette transporter protein thought to act as an FLC efflux pump. Mutations in the gene that render the transcription factor hyperactive are the most common cause of fluconazole resistance among clinical isolates.
View Article and Find Full Text PDFAntipsychotic Drugs and Cognitive Function: A Systematic Review and Network Meta-Analysis.
JAMA Psychiatry
January 2025
Technical University of Munich, TUM School of Medicine and Health, Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Munich, Germany.
Article Synopsis
- Cognitive deficits significantly impact individuals with schizophrenia spectrum disorders (SSDs), and while antipsychotics are commonly used, they don’t enhance cognition and vary in their effectiveness based on their receptor profiles.
- The study aimed to assess the relationship between various antipsychotic treatments and cognitive performance in SSD patients by analyzing numerous randomized clinical trials.
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Objective: This study aims to compare the risks of different antipsychotics in causing hyperprolactinemia, taking into account the age, gender, and onset time.
Materials And Methods: We searched the FDA Adverse Event Reporting System (FAERS) from January 1, 2004, to March 31, 2022, for reports of hyperprolactinemia treated with antipsychotics. We evaluated the association between antipsychotics and the risk of hyperprolactinemia using reporting odds ratio (ROR) based on a disproportionality analysis.
Similarities and distinctions in the activation of the Pdr1 regulatory pathway by azole and non-azole drugs.
bioRxiv
September 2024
Departments of Molecular Physiology and Biophysics and Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Incidences of fluconazole (FLC) resistance among clinical isolates is a growing issue in clinics. The pleiotropic drug response (PDR) network in . confers azole resistance and is defined primarily by the ZnCys zinc cluster-containing transcription factor Pdr1 and target genes such as , that encodes an ATP-binding cassette transporter protein thought to act as a FLC efflux pump.
View Article and Find Full Text PDFDopamine mediates a directionally opposite correlation between empathy and the reinforcing effects of amphetamine and gambling in people with gambling disorder vs. healthy controls.
Pharmacol Biochem Behav
December 2024
Molecular Brain Sciences Dept., Centre for Addiction & Mental Health, Toronto, ON M5T 1R8, Canada; Dept. of Psychiatry, University of Toronto, Toronto, ON M5S 1A8, Canada.
Understanding the relationship between empathy, subjective effects of addictive reinforcers and dopamine function in people with gambling disorder (PGD) vs. healthy controls (HCs) may inform GD treatment. The current investigation addressed this issue via retrospective analysis of data from three studies using amphetamine and a slot machine (SLOTS) as reinforcers in PGD and HCs.
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