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From interference to insight: pseudo-lipidemia led to the diagnosis of Waldenström macroglobulinemia.
BMC Cardiovasc Disord
March 2025
Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifu Yuan, Dongcheng District, Beijing, 100730, China.
Waldenström macroglobulinemia (WM) is a rare hematological disorder with an annual incidence of about 3 per million. Its clinical manifestations are diverse and non - specific, and approximately 30% of patients are asymptomatic, making early diagnosis challenging. This paper reports a 73-year-old female who was admitted to the hospital due to atrial fibrillation.
View Article and Find Full Text PDFRetrospective analysis of treatment discontinuation in minimal residual disease negative multiple myeloma.
Int J Hematol
March 2025
Division of Hematology, Shonan Kamakura General Hospital, 1370-1, Okamoto, Kamakura, Kanagawa, 247-0072, Japan.
Background: The prognostic significance of minimal residual disease (MRD) negativity in multiple myeloma (MM) is well-established, and MRD negativity serves as a surrogate marker for treatment outcomes. However, in various clinical trials, achieving MRD negativity often leads to treatment continuation until disease progression. In real-world clinical practice, discontinuing treatment could lower healthcare costs and reduce adverse events.
View Article and Find Full Text PDF[Screening and Preliminary Validation of Multiple Myeloma Specific Proteins].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
February 2025
Department of Hematology, Peking University First Hospital, Beijing 100032, China.
Objective: To screen novel diagnostic marker or therapeutic target for multiple myeloma (MM).
Methods: and were identified by bioinformatics method based on GEO database as high expression genes in MM. Their RNA and protein expression levels in bone marrow mononuclear cells from myeloma cell lines U266, NCI-H929, MM.
Case Report of HIV and Neurosyphilis Coinfection in a Recent Migrant: Old Diseases in New Faces.
Clin Pract Cases Emerg Med
January 2025
Chobanian & Avedisian School of Medicine, Department of Emergency Medicine, Boston University, Boston, Massachusetts.
Introduction: Coinfection with human immunodeficiency virus (HIV) and Treponema pallidum represents a unique challenge in management, with increased risk of neurological complications. Haiti is well-known for being disproportionately impacted by the HIV epidemic, with rates of infection ~6 times higher than in the United States (US). Rates of coinfection in Haiti are incompletely characterized but likely high.
View Article and Find Full Text PDFA Bayesian Joint Model of Multiple Nonlinear Longitudinal and Competing Risks Outcomes for Dynamic Prediction in Multiple Myeloma: Joint Estimation and Corrected Two-Stage Approaches.
Stat Med
February 2025
Hoffmann-La Roche Ltd, Basel, Switzerland.
Predicting cancer-associated clinical events is challenging in oncology. In Multiple Myeloma (MM), a cancer of plasma cells, disease progression is determined by changes in biomarkers, such as serum concentration of the paraprotein secreted by plasma cells (M-protein). Therefore, the time-dependent behavior of M-protein and the transition across lines of therapy (LoT), which may be a consequence of disease progression, should be accounted for in statistical models to predict relevant clinical outcomes.
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